{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:32:17Z","timestamp":1793845937239,"version":"4.6.1"},"reference-count":29,"publisher":"Massachusetts Medical Society","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2014,11,13]]},"DOI":"10.1056\/nejmoa1406037","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T10:00:31Z","timestamp":1411984831000},"page":"1877-1888","source":"Crossref","is-referenced-by-count":1733,"title":["Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma"],"prefix":"10.1056","volume":"371","author":[{"given":"Georgina V.","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniil","family":"Stroyakovskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Gogas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Levchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"de Braud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Larkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Garbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jouary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Hauschild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Jacques","family":"Grob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanna","family":"Chiarion Sileni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Lebbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mandal\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Millward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Arance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Bondarenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.A.G.","family":"Haanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Utikal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Ferraresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda","family":"Kovalenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volodymyr","family":"Probachai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"DeMarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhangir G.","family":"Irani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Casey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Ouellet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngocdiep","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Flaherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"r003","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1200\/jco.2012.30.15_suppl.8502","volume":"30","author":"Chapman PB","year":"2012","journal-title":"J Clin Oncol"},{"key":"r004","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.1200\/jco.2013.31.15_suppl.9013","volume":"31","author":"Hauschild A","year":"2013","journal-title":"J Clin Oncol"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3122"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0617"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0642"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1038\/nature08833"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1038\/nature08902"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.040"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208958"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105358"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.7680"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203421"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605714"},{"key":"r016","doi-asserted-by":"publisher","first-page":"8503","DOI":"10.1200\/jco.2011.29.18_suppl.cra8503","volume":"29","author":"Infante JR","year":"2011","journal-title":"J Clin Oncol"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210093"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104621"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1727"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1038\/nature09626"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1038\/nature10662"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.2312"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.11.023"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112302"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60398-5"},{"key":"r029","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.8691"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000110"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1406037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T23:17:29Z","timestamp":1598311049000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1406037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,13]]},"references-count":29,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2014,11,13]]}},"alternative-id":["10.1056\/NEJMoa1406037"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1406037","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,13]]}}}