{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:56:19Z","timestamp":1792896979858,"version":"4.5.0"},"reference-count":25,"publisher":"Massachusetts Medical Society","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2015,6,25]]},"DOI":"10.1056\/nejmoa1503093","type":"journal-article","created":{"date-parts":[[2015,4,19]],"date-time":"2015-04-19T08:31:28Z","timestamp":1429432288000},"page":"2521-2532","source":"Crossref","is-referenced-by-count":5354,"title":["Pembrolizumab versus Ipilimumab in Advanced Melanoma"],"prefix":"10.1056","volume":"372","author":[{"given":"Caroline","family":"Robert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Schachter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina V.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Arance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Jacques","family":"Grob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mortier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Daud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo S.","family":"Carlino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"McNeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Lotem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Larkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lorigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Neyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian U.","family":"Blank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mateus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Shapira-Frommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Kosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nageatte","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scot","family":"Ebbinghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.5568"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-116"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5256.1734"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3239"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104621"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.41.6750"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3259"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm057"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1205943"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305133"},{"key":"r012","first-page":"1223","volume":"27","author":"Ribas A","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60958-2"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302369"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0105"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412082"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1624"},{"key":"r020","first-page":"LBA34","volume":"25","author":"Robert C","year":"2014","journal-title":"Ann Oncol"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-051482"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-255125"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-006-0272-1"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1038\/nature13954"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1348"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1503093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T17:27:41Z","timestamp":1494264461000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1503093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,25]]},"references-count":25,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2015,6,25]]}},"alternative-id":["10.1056\/NEJMoa1503093"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1503093","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725442696.793524100","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725442696.793519588","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,25]]}}}