{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:33:08Z","timestamp":1792038788509,"version":"4.4.0"},"reference-count":25,"publisher":"Massachusetts Medical Society","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2016,5,12]]},"DOI":"10.1056\/nejmoa1505971","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T21:02:17Z","timestamp":1463000537000},"page":"1811-1821","source":"Crossref","is-referenced-by-count":589,"title":["Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function"],"prefix":"10.1056","volume":"374","author":[{"given":"Prescott G.","family":"Woodruff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Graham","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Bleecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Christenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Couper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Gouskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia N.","family":"Hansel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Kanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Kleerup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Lazarus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando J.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Robert","family":"Paine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Rennard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"Tashkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MeiLan K.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201204-0596PP"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.11.003"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-13"},{"key":"r004","first-page":"1557","volume":"6","author":"Johns DP","year":"2014","journal-title":"J Thorac Dis"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00000315"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203897"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00102509"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-059OC"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00259"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.7.581"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-68"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00195212"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00036513"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00694.2009"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.13.1477"},{"key":"r020","first-page":"775","volume":"1","year":"1965","journal-title":"Lancet"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00242-8"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00180812"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-205048"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2946"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2570"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.2735"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1505971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T19:34:52Z","timestamp":1478115292000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1505971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,12]]},"references-count":25,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2016,5,12]]}},"alternative-id":["10.1056\/NEJMoa1505971"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1505971","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,12]]}}}