{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:35:48Z","timestamp":1792856148632,"version":"4.5.0"},"reference-count":28,"publisher":"Massachusetts Medical Society","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2016,5,26]]},"DOI":"10.1056\/nejmoa1511769","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T17:13:41Z","timestamp":1464196421000},"page":"2044-2053","source":"Crossref","is-referenced-by-count":436,"title":["Factor VIII\u2013Mimetic Function of Humanized Bispecific Antibody in Hemophilia A"],"prefix":"10.1056","volume":"374","author":[{"given":"Midori","family":"Shima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideji","family":"Hanabusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Taki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Fukutake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Fukazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Yoneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Nogami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01189.x"},{"key":"r002","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1055\/s-0037-1615621","volume":"85","author":"White GC","year":"2001","journal-title":"Thromb Haemost"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02806.x"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12429"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1976.tb16525.x"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02909.x"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01494.x"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01843.x"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12428"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01526.x"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02383.x"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02687.x"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02663.x"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104435"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-369132"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2014.930768"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-04-0231"},{"key":"r019","doi-asserted-by":"crossref","unstructured":"DiMichele DM. Inhibitors to factor VIII\/IX: immune tolerance. In: Lee CA, Berntorp EE, Hoots WK, eds. Textbook of hemophilia. 3rd ed. Malden, MA: Wiley-Blackwell, 2014:64-71.","DOI":"10.1002\/9781118398258.ch9"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2942"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057479"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12474"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-650226"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-585737"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.10.012"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12672"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.9.s1.17.x"},{"key":"r029","doi-asserted-by":"publisher","DOI":"10.4161\/self.1.4.13904"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1511769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:39:29Z","timestamp":1567964369000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1511769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":28,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2016,5,26]]}},"alternative-id":["10.1056\/NEJMoa1511769"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1511769","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726378844.793544814","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726378844.793520037","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726378844.793519900","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726378844.793526182","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}