{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T08:55:47Z","timestamp":1794128147441,"version":"4.8.0"},"reference-count":35,"publisher":"Massachusetts Medical Society","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2015,11,26]]},"DOI":"10.1056\/nejmoa1511939","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T14:34:41Z","timestamp":1447079681000},"page":"2103-2116","source":"Crossref","is-referenced-by-count":5637,"title":["A Randomized Trial of Intensive versus Standard Blood-Pressure Control"],"prefix":"10.1056","volume":"373","author":[{"name":"The SPRINT Research Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70151-3"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000441139.02102.80"},{"key":"r003","first-page":"594","volume":"47","author":"Franklin SS","year":"1999","journal-title":"Pathol Biol (Paris)"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.3.869"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90944-Z"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.923"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1001\/jama.275.20.1557"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90878-9"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11911-8"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05381-6"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003417"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0773"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61766-8"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03307-9"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1001\/jama.277.9.739"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1001\/jama.265.24.3255"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801369"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.2115"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.146035"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61340-4"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001286"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60852-1"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1177\/1740774514537404"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67573-3"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"r029","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000203309.07140.d3"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/75.2.383"},{"key":"r033","unstructured":"Proschan MA, Lan KKG, Wittes JT. Statistical monitoring of clinical trials: a unified approach. New York: Springer, 2006."},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.2307\/2670170"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.5.685"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.111"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000194120.42722.ac"},{"key":"r038","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2334"},{"key":"r039","first-page":"1","volume":"133","author":"Nwankwo T","year":"2013","journal-title":"NCHS Data Brief"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1511939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T10:43:28Z","timestamp":1504262608000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1511939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":35,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2015,11,26]]}},"alternative-id":["10.1056\/NEJMoa1511939"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1511939","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725924077.793512281","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725924077.793530922","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725924077.793511288","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725924077.793511528","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725924077.793527680","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725924077.793511763","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]}}}