{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:57:23Z","timestamp":1791424643977,"version":"4.3.3"},"reference-count":41,"publisher":"Massachusetts Medical Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2016,3,17]]},"DOI":"10.1056\/nejmoa1512234","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T17:03:45Z","timestamp":1458147825000},"page":"1032-1043","source":"Crossref","is-referenced-by-count":245,"title":["Loss of B Cells in Patients with Heterozygous Mutations in IKAROS"],"prefix":"10.1056","volume":"374","author":[{"given":"Hye Sun","family":"Kuehn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Boisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cunningham-Rundles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Reichenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rg","family":"Stray-Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin W.","family":"Gelfand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Maffucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith R.","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan K.","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl V.","family":"Voelkerding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah T.","family":"South","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy H.","family":"Augustine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeana S.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K.","family":"Dolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty B.","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Itan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelie","family":"Cobat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne S\u00f8rmo","family":"Sorte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundar","family":"Ganesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seraina","family":"Prader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica G.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan S.","family":"Orange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine R.","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E.","family":"Niemela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Fleisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry R.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Kum\u00e1novics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ellen","family":"Conley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio D.","family":"Rosenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07669.x"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1077"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.07.008"},{"key":"r004","first-page":"162","volume":"5","author":"Al-Herz W","year":"2014","journal-title":"Front Immunol"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2771"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.09.009"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.05.004"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-661"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1038\/ng.909"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20100"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1644-5"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.11.10.5229"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439790"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80033-3"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1101\/gad.816400"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80472-9"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.03.006"},{"key":"r018","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1002\/j.1460-2075.1996.tb00920.x","volume":"15","author":"Sun L","year":"1996","journal-title":"EMBO J"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605627200"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00168-7"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23160"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112533"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.11.020"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-515528"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260791"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255904"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234864"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71927"},{"key":"r029","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301992"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000229482.27398.ad"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90407-3"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80269-1"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200203)32:3<720::AID-IMMU720>3.0.CO;2-P"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90170-1"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.680"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808253"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040934"},{"key":"r038","first-page":"1","volume":"3","author":"Kastner P","year":"2013","journal-title":"Am J Blood Res"},{"key":"r039","doi-asserted-by":"publisher","DOI":"10.1038\/ng.430"},{"key":"r040","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200235"},{"key":"r041","doi-asserted-by":"crossref","first-page":"866","DOI":"10.4049\/jimmunol.156.2.866","volume":"156","author":"Nu\u00f1ez C","year":"1996","journal-title":"J Immunol"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1512234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T03:16:17Z","timestamp":1692242177000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1512234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,3,17]]}},"alternative-id":["10.1056\/NEJMoa1512234"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1512234","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726221084.793529877","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}