{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:48:06Z","timestamp":1791920886541,"version":"4.3.4"},"reference-count":17,"publisher":"Massachusetts Medical Society","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1056\/nejmoa1602046","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T17:01:36Z","timestamp":1480525296000},"page":"2133-2143","source":"Crossref","is-referenced-by-count":460,"title":["Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women"],"prefix":"10.1056","volume":"375","author":[{"given":"Annalene","family":"Nel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neli\u00ebtte","family":"van Niekerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saidi","family":"Kapiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda-Gail","family":"Bekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Gama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoli","family":"Kamali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Kotze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Louw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonke","family":"Mabude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nokuthula","family":"Miti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Kusemererwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Tempelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannelie","family":"Carstens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brid","family":"Devlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00ebtte","family":"Malherbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winel","family":"Mans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Nuttall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smangaliso","family":"Ntshele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlie","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Solai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Spence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Steytler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Windle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Borremans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Resseler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Van Roey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Parys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Vangeneugden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Van Baelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeda","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089118"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832c413d"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.4433"},{"key":"r010","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa1506110","volume":"375","author":"Baeten JM","year":"2016","journal-title":"N Engl J Med"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202614"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402269"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147743"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.03.023"},{"key":"r017","first-page":"132","volume":"23","author":"Wensing AM","year":"2015","journal-title":"Top Antivir Med"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020298"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108524"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193748"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.16.1.18505"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000801"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-186"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu266"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1602046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T00:54:32Z","timestamp":1498352072000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1602046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":17,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1056\/NEJMoa1602046"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1602046","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727103205.793526928","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}