{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:10:49Z","timestamp":1792444249894,"version":"4.5.0"},"reference-count":38,"publisher":"Massachusetts Medical Society","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2016,12,15]]},"DOI":"10.1056\/nejmoa1610020","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T02:00:47Z","timestamp":1475287247000},"page":"2335-2348","source":"Crossref","is-referenced-by-count":1911,"title":["Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis"],"prefix":"10.1056","volume":"375","author":[{"given":"Eric L.","family":"Simpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Guttman-Yassky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Blauvelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Cork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan I.","family":"Silverberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Deleuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Lacour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fclli","family":"Kingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Poulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wollenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhwen","family":"Soo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.H.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Pirozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolanle","family":"Akinlade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Staudinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Mastey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Gadkari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Yancopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Ardeleanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000110"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.012"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01027.x"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0567-4"},{"key":"r005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ad.2012.03.008","volume":"104","author":"S\u00e1nchez-P\u00e9rez J","year":"2013","journal-title":"Actas Dermosifiliogr"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.10.043"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13599"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04635.x"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.030"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.013"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.2217\/imt.15.69"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4624"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00388-8"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.04.054"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304048"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30307-5"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.19330"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.023"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.062"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.100102.x"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02719.x"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1246"},{"key":"r024","doi-asserted-by":"crossref","first-page":"636","DOI":"10.2340\/00015555-1129","volume":"91","author":"Reich A","year":"2011","journal-title":"Acta Derm Venereol"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03112.x"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1159\/000365390"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.12.1513"},{"key":"r029","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.07.001"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00896-X"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.010"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.07.052"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.020"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.08.008"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1521\/suli.2006.36.1.120"},{"key":"r038","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.041"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1610020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T12:55:48Z","timestamp":1509627348000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1610020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,15]]},"references-count":38,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2016,12,15]]}},"alternative-id":["10.1056\/NEJMoa1610020"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1610020","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726815273.793525101","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726815273.793527741","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726815273.793525644","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,15]]}}}