{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:32:14Z","timestamp":1792751534102,"version":"4.5.0"},"reference-count":26,"publisher":"Massachusetts Medical Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2017,2,2]]},"DOI":"10.1056\/nejmoa1611770","type":"journal-article","created":{"date-parts":[[2016,12,3]],"date-time":"2016-12-03T13:01:07Z","timestamp":1480770067000},"page":"429-439","source":"Crossref","is-referenced-by-count":850,"title":["Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease"],"prefix":"10.1056","volume":"376","author":[{"given":"Kenneth I.","family":"Ataga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Kutlar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Kanter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darla","family":"Liles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Cancado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Friedrisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy H.","family":"Guthrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Knight-Madden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofelia A.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor R.","family":"Gordeuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gualandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina P.","family":"Colella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wally R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Rollins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Stocker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell P.","family":"Rother","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20336"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21731"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302303"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-383430"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709113371107"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005013021803"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-498311"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(97)90005-6"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.06.001"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1080\/mic.11.2.167.177"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90393-D"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1955"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0626"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0713"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.211615"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052522799"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-285718"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23147"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.585828"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007932"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322001"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1645"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21968"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08520.x"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512021"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1611770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T17:08:42Z","timestamp":1485968922000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1611770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,2,2]]}},"alternative-id":["10.1056\/NEJMoa1611770"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1611770","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}