{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:36:17Z","timestamp":1792622177116,"version":"4.5.0"},"reference-count":31,"publisher":"Massachusetts Medical Society","issue":"1","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100012399","name":"Biomedical Advanced Research and Development Authority","doi-asserted-by":"crossref","award":["HHSO100201100001C"],"award-info":[{"award-number":["HHSO100201100001C"]}],"id":[{"id":"10.13039\/100012399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN266200600014C"],"award-info":[{"award-number":["HHSN266200600014C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2018,7,5]]},"DOI":"10.1056\/nejmoa1705688","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T17:01:16Z","timestamp":1530723676000},"page":"44-53","source":"Crossref","is-referenced-by-count":375,"title":["Oral Tecovirimat for the Treatment of Smallpox"],"prefix":"10.1056","volume":"379","author":[{"given":"Douglas W.","family":"Grosenbach","sequence":"first","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kady","family":"Honeychurch","sequence":"additional","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Rose","sequence":"additional","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarasvech","family":"Chinsangaram","sequence":"additional","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Frimm","sequence":"additional","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Maiti","sequence":"additional","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Lovejoy","sequence":"additional","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Meara","sequence":"additional","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Long","sequence":"additional","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Hruby","sequence":"additional","affiliation":[{"name":"From SIGA Technologies, Corvallis, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","unstructured":"Virus taxonomy: the classification and nomenclature of viruses \u2014 9th Report of the ICTV. Amsterdam: Elsevier 2012 (https:\/\/talk.ictvonline.org\/taxonomy\/)."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/425745"},{"key":"e_1_3_4_4_2","volume-title":"Smallpox and its eradication","author":"Fenner F","year":"1988","unstructured":"Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. Smallpox and its eradication. Geneva: World Health Organization, 1988."},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5406.1279"},{"key":"e_1_3_4_6_2","unstructured":"Gellman B. 4 Nations thought to possess smallpox. Washington Post. November 5 2002."},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.357.6347.115"},{"key":"e_1_3_4_8_2","unstructured":"Food and Drug Administration. New drug and biological drug products: evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Fed Regist 2002;67(105):37988-37998.12049094"},{"key":"e_1_3_4_9_2","unstructured":"CDER drug and biologic animal rule approvals. March 30 2018 (https:\/\/www.fda.gov\/downloads\/Drugs\/DevelopmentApprovalProcess\/HowDrugsareDevelopedandApproved\/DrugandBiologicApprovalReports\/NDAandBLAApprovalReports\/UCM578137.pdf)."},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.13139-13149.2005"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.11.5910-5920.1991"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2005.11.006"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.1.272-281.1996"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-50-1-89"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-83-12-2915"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.8.4732-4741.1993"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/135965350701200802"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.03.005"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00879-06"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00762-07"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.76.768"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00021-09"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01596-08"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00977-13"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00423-07"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02331"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00208-15"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00904-12"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01689-09"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00959-12"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01303-07"},{"key":"e_1_3_4_32_2","volume-title":"Product development under the animal rule. Guidance for Industry.","year":"2015","unstructured":"Product development under the animal rule. Guidance for Industry. Silver Spring, MD: Center for Biologics Evaluation and Research, October 2015."}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1705688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T20:48:48Z","timestamp":1711486128000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1705688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7,5]]}},"alternative-id":["10.1056\/NEJMoa1705688"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1705688","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733576187.793551735","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]}}}