{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:56:29Z","timestamp":1792659389785,"version":"4.5.0"},"reference-count":35,"publisher":"Massachusetts Medical Society","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2017,11,16]]},"DOI":"10.1056\/nejmoa1710030","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T11:30:42Z","timestamp":1509795042000},"page":"1930-1942","source":"Crossref","is-referenced-by-count":594,"title":["Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease"],"prefix":"10.1056","volume":"377","author":[{"given":"Vicente E.","family":"Torres","sequence":"first","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene B.","family":"Chapman","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Devuyst","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron T.","family":"Gansevoort","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald D.","family":"Perrone","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Koch","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ouyang","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"McQuade","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime D.","family":"Blais","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank S.","family":"Czerwiec","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Sergeyeva","sequence":"additional","affiliation":[{"name":"From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60907-2"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.59"},{"key":"r003","unstructured":"Renal Data System. USRDS 2013 annual data report: atlas of chronic kidney disease and end-stage renal disease in the United States. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases, 2013."},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.109"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00843.x"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00243.2011"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030251"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00345.2014"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1999)24:3\/4<309::AID-DVG14>3.0.CO;2-5"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1038\/nm935"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1038\/nm1004"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004121090"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013121312"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.213256"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007060688"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205511"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx079"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-015-0327-3"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1159\/000456087"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008050507"},{"key":"r021","unstructured":"Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research, Center for Device and Radiological Health. Enrichment strategies for clinical trials to support approval of human drugs and biological products: guidance for industry. Rockville, MD: Food and Drug Administration, December 2012."},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-4-200608150-00004"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.119"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.285"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06300615"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.22"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.325"},{"key":"r029","doi-asserted-by":"crossref","unstructured":"Devuyst O, Chapman AB, Shoaf SE, Czerwiec FS, Blais JD. Tolerability of aquaretic-related symptoms following tolvaptan for autosomal dominant polycystic kidney disease: results from TEMPO 3:4. Kidney Int Rep 2017 July 20 (Epub ahead of print).","DOI":"10.1016\/j.ekir.2017.07.004"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013101138"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015010016"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1159\/000445450"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.01.003"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.02.011"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00495.2016"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1710030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T12:08:56Z","timestamp":1570277336000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1710030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,16]]},"references-count":35,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2017,11,16]]}},"alternative-id":["10.1056\/NEJMoa1710030"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1710030","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732079787.793555196","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,16]]}}}