{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:22:02Z","timestamp":1792041722177,"version":"4.4.0"},"reference-count":27,"publisher":"Massachusetts Medical Society","issue":"22","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["11\/129\/197"],"award-info":[{"award-number":["11\/129\/197"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2018,5,31]]},"DOI":"10.1056\/nejmoa1801214","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T08:50:20Z","timestamp":1524559820000},"page":"2105-2114","source":"Crossref","is-referenced-by-count":354,"title":["A Randomized Trial of Early Endovenous Ablation in Venous Ulceration"],"prefix":"10.1056","volume":"378","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5685-0723","authenticated-orcid":false,"given":"Manjit S.","family":"Gohel","sequence":"first","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Heatley","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxue","family":"Liu","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bradbury","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bulbulia","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Cullum","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Epstein","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Nyamekye","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith R.","family":"Poskitt","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Renton","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Warwick","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5261-6913","authenticated-orcid":false,"given":"Alun H.","family":"Davies","sequence":"additional","affiliation":[{"name":"From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","first-page":"CD000265","article-title":"Compression for venous leg ulcers.","volume":"11","author":"O\u2019Meara S","year":"2012","unstructured":"O\u2019Meara S, Cullum N, Nelson EA, Dumville JC. Compression for venous leg ulcers. Cochrane Database Syst Rev 2012;11:CD000265-CD000265.23152202","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615243"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1906"},{"key":"e_1_3_5_5_2","unstructured":"Varicose veins in the legs CG168: the diagnosis and management of varicose veins. London: National Institute for Health and Care Excellence 2013 (https:\/\/www.nice.org.uk\/guidance\/cg168)."},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400781"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2013.04.008"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16353-8"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39216.542442.BE"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.059"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.04.053"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2017.02.007"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2017.02.028"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.049"},{"issue":"10","key":"e_1_3_5_15_2","first-page":"CD009494","article-title":"Endovenous thermal ablation for healing venous ulcers and preventing recurrence.","author":"Samuel N","year":"2013","unstructured":"Samuel N, Carradice D, Wallace T, Smith GE, Chetter IC. Endovenous thermal ablation for healing venous ulcers and preventing recurrence. Cochrane Database Syst Rev 2013;10:CD009494-CD009494.24096603","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_5_16_2","unstructured":"National Institute for Health Research. EVRA study protocol (https:\/\/www.journalslibrary.nihr.ac.uk\/programmes\/hta\/11129197)."},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.01.079"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62368-5"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.05.117"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2.1.5"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hec.3564"},{"key":"e_1_3_5_23_2","unstructured":"Grothier L. Leg ulcer management guidelines. Essex England: Provide Community Interest Company 2017 (http:\/\/www.legulcerforum.org\/downloads\/LUF_Leg_Ulcer_Clinical_Guidelines_15.pdf)."},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12814"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12605"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)70002-2"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4837"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1894"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1801214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T20:46:25Z","timestamp":1711485985000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1801214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":27,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2018,5,31]]}},"alternative-id":["10.1056\/NEJMoa1801214"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1801214","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733101243.793547790","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,31]]}}}