{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:47:48Z","timestamp":1792226868975,"version":"4.4.0"},"reference-count":20,"publisher":"Massachusetts Medical Society","issue":"26","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2018,6,28]]},"DOI":"10.1056\/nejmoa1804092","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T14:22:24Z","timestamp":1526912544000},"page":"2486-2496","source":"Crossref","is-referenced-by-count":1882,"title":["Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma"],"prefix":"10.1056","volume":"378","author":[{"given":"Mario","family":"Castro","sequence":"first","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Corren","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Pavord","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Maspero","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Wenzel","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus F.","family":"Rabe","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Busse","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Ford","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Sher","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Mark","family":"FitzGerald","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Katelaris","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Tohda","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Staudinger","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Pirozzi","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Amin","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Ruddy","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolanle","family":"Akinlade","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Khan","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdong","family":"Chao","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Martincova","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.H.","family":"Graham","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian N.","family":"Swanson","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Stahl","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Yancopoulos","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Teper","sequence":"additional","affiliation":[{"name":"From the Washington University School of Medicine, St. Louis (M.C.); David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (J. Corren), and Peninsula Research Associates, Rolling Hills Estates (L.S.) \u2014 both in California; Oxford Respiratory National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (I.D.P.); Fundaci\u00f3n CIDEA (Centro de Investigaci\u00f3n de Enfermedades Al\u00e9rgicas y Respiratorias), Buenos Aires (J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-033OC"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770900903518835"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.03.031"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210531"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810223391703"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3786"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12880"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1298443"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1323896111"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31191-1"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610020"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00388-8"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30307-5"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804093"},{"key":"e_1_3_5_16_2","unstructured":"Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. 2015 (http:\/\/ginasthma.org\/wp-content\/uploads\/2016\/01\/GINA_Report_2015_Aug11-1.pdf)."},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.10.008"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.5.1265"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-060ST"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01785-2017"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3838"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1804092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T20:43:36Z","timestamp":1711485816000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1804092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":20,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2018,6,28]]}},"alternative-id":["10.1056\/NEJMoa1804092"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1804092","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733272126.793550788","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.733272126.793571854","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,28]]}}}