{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:42:54Z","timestamp":1792100574388,"version":"4.4.0"},"reference-count":41,"publisher":"Massachusetts Medical Society","issue":"16","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CSP 573"],"award-info":[{"award-number":["CSP 573"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2019,10,17]]},"DOI":"10.1056\/nejmoa1811424","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T17:01:28Z","timestamp":1571245288000},"page":"1513-1523","source":"Crossref","is-referenced-by-count":251,"title":["Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn"],"prefix":"10.1056","volume":"381","author":[{"given":"Stuart J.","family":"Spechler","sequence":"first","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Hunter","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Smith","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mashimo","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian M.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry B.","family":"Dunbar","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thai H.","family":"Pham","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma K.","family":"Murthy","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taewan","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian S.","family":"Jackson","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Wallen","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C.","family":"von Rosenvinge","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Pearl","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren","family":"Laine","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony W.","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Kaz","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger P.","family":"Tatum","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad F.","family":"Gellad","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Lagoo-Deenadayalan","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel H.","family":"Rubenstein","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir A.","family":"Ghaferi","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Kit","family":"Lo","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald S.","family":"Fernando","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby S.","family":"Chan","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley C.","family":"Paski","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Provenzale","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald O.","family":"Castell","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lieberman","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda F.","family":"Souza","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Chey","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart R.","family":"Warren","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Davis-Karim","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby D.","family":"Melton","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Genta","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Serpi","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousick","family":"Biswas","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant D.","family":"Huang","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Baylor Scott &amp; White Health, and the Department of Medicine, Veterans Affairs (VA) North Texas Health Care System (S.J.S., R.F.S.), and the Departments of Medicine (K.B.D.), Surgery (T.H.P.), and Pathology (S.D.M.), VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, and the Department of Pathology, Baylor College of Medicine, Houston (R.M.G...."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.015"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01588.x"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.1.45"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.444"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.50"},{"issue":"11","key":"e_1_3_5_8_2","first-page":"29","article-title":"How satisfied are chronic heartburn sufferers with their prescription medications? Results of the Patient Unmet Needs Survey.","volume":"7","author":"Crawley JA","year":"2000","unstructured":"Crawley JA, Schmitt CM. How satisfied are chronic heartburn sufferers with their prescription medications? Results of the Patient Unmet Needs Survey. J Clin Outcomes Manag 2000;7(11):29-34.","journal-title":"J Clin Outcomes Manag"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145581"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.08.003"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.012"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.012"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/307805"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.06.025"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.279"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301897"},{"issue":"9","key":"e_1_3_5_17_2","first-page":"1","article-title":"A review of medical therapy for proton pump inhibitor nonresponsive gastroesophageal reflux disease.","volume":"30","author":"Hillman L","year":"2017","unstructured":"Hillman L, Yadlapati R, Thuluvath AJ, Berendsen MA, Pandolfino JE. A review of medical therapy for proton pump inhibitor nonresponsive gastroesophageal reflux disease. Dis Esophagus 2017;30(9):1-15.28859358","journal-title":"Dis Esophagus"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.049"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-007-9490-7"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12838"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.256"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.05.023"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2007.00658.x"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/58.3.403"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205544"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/75.4.800"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-008-0098-4"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.033"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03191.x"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.6.885"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03393.x"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2010.03.006"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-017-5759-7"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.010"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14528"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5493"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-2861-3"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12715"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00553-0"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13233"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.013"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9830-4"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1811424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T20:58:38Z","timestamp":1711486718000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1811424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,17]]},"references-count":41,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,10,17]]}},"alternative-id":["10.1056\/NEJMoa1811424"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1811424","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736759491.793567083","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,17]]}}}