{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:55:25Z","timestamp":1792292125607,"version":"4.4.0"},"reference-count":12,"publisher":"Massachusetts Medical Society","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2021,6,3]]},"DOI":"10.1056\/nejmoa2104882","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T10:01:17Z","timestamp":1617962477000},"page":"2124-2130","source":"Crossref","is-referenced-by-count":1302,"title":["Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination"],"prefix":"10.1056","volume":"384","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9194-4952","authenticated-orcid":false,"given":"Nina H.","family":"Schultz","sequence":"first","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild H.","family":"S\u00f8rvoll","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika E.","family":"Michelsen","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvig A.","family":"Munthe","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fridtjof","family":"Lund-Johansen","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Ahlen","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wiedmann","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Hege","family":"Aamodt","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor H.","family":"Skatt\u00f8r","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir E.","family":"Tj\u00f8nnfjord","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l A.","family":"Holme","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, L\u00f8renskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Troms\u00f8 (I.H.S., M.T.A.) \u2014 all in Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","unstructured":"WHO Coronavirus (COVID-19) Dashboard. Geneva: World Health Organization. April 5 2021 (https:\/\/covid19.who.int\/)."},{"key":"e_1_3_5_3_2","unstructured":"Norwegian Institute of Public Health. COVID 19 Ukerapport \u2014 uke 10 March 17 2021 (https:\/\/www.fhi.no\/contentassets\/8a971e7b0a3c4a06bdbf381ab52e6157\/vedlegg\/2021\/ukerapport-for-uke-10-08.03---14.03.21.pdf)."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03645.x"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2012.724736"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13516"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2010540117"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPG0MNR5NGKNFX"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13813"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-540781"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900196"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15105"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32466-1"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2104882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T18:27:25Z","timestamp":1749666445000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2104882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,3]]},"references-count":12,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,6,3]]}},"alternative-id":["10.1056\/NEJMoa2104882"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2104882","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739901863.793584823","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,3]]}}}