{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:04:37Z","timestamp":1792587877213,"version":"4.5.0"},"reference-count":36,"publisher":"Massachusetts Medical Society","issue":"22","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["1406-18876"],"award-info":[{"award-number":["1406-18876"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2021,11,25]]},"DOI":"10.1056\/nejmoa2113514","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T14:41:46Z","timestamp":1633876906000},"page":"2025-2035","source":"Crossref","is-referenced-by-count":459,"title":["Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults"],"prefix":"10.1056","volume":"385","author":[{"given":"Mark D.","family":"Neuman","sequence":"first","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Carson","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakisha J.","family":"Gaskins","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Dillane","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I.","family":"Sessler","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Sieber","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Magaziner","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Marcantonio","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Mehta","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Menio","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabry","family":"Ayad","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Stone","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Papp","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Schwenk","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Elkassabany","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Marshall","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Douglas","family":"Jaffe","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Luke","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balram","family":"Sharma","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Azim","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Hymes","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; 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Kwesi","family":"Kwofie","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.); the Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton (D.D.), the Department of Orthopaedics, University of British Columbia, Vancouver (T.S.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoun","family":"Nader","sequence":"additional","affiliation":[{"name":"From the Departments of Anesthesiology and Critical Care (M.D.N., L.J.G., N.E., L.A.F.), Biostatistics, Epidemiology, and Informatics (R.F., A.J.S.-S., S.S.E.), and Orthopedic Surgery (S.M.) and the Centers for Perioperative Outcomes Research and Transformation (M.D.N., L.J.G., N.E., L.A.F.) and Clinical Epidemiology and Biostatistics (R.F., J.D., A.T., A.J.S.-S., S.S.E.), University of Pennsylvania Perelman School of Medicine, the Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University (E.S.S.), the Center for Advocacy for the Rights and Interests of the Elderly (D.M.), and the Department of Anesthesiology, Lewis Katz School of Medicine at Temple University (E.H.), Philadelphia; 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