{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:37:35Z","timestamp":1792247855058,"version":"4.4.0"},"reference-count":22,"publisher":"Massachusetts Medical Society","issue":"12","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2022,3,24]]},"DOI":"10.1056\/nejmoa2119115","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T16:32:17Z","timestamp":1645115537000},"page":"1132-1142","source":"Crossref","is-referenced-by-count":967,"title":["Darolutamide and Survival in Metastatic, Hormone-Sensitive Prostate Cancer"],"prefix":"10.1056","volume":"386","author":[{"given":"Matthew R.","family":"Smith","sequence":"first","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Hussain","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Fizazi","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora N.","family":"Sternberg","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. David","family":"Crawford","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Kopyltsov","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandler H.","family":"Park","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Alekseev","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Montesa-Pino","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingwei","family":"Ye","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Parnis","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-4850","authenticated-orcid":false,"given":"Felipe","family":"Cruz","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teuvo L.J.","family":"Tammela","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapio","family":"Utriainen","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Fu","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohide","family":"Uemura","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"M\u00e9ndez-Vidal","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Maughan","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); the University of Montreal Hospital Center, Montreal (F.S.); Institut Gustave Roussy, University of Paris\u2013Saclay, Villejuif, France (K.F.); the Englander Institute for Precision Medicine, Weill Cornell Medicine, Meyer Cancer Center, New York\u2013Presbyterian Hospital, New York (C.N.S.); the University of California San Diego School of Medicine, La Jolla (E.D.C.); the Clinical Oncologic Dispensary of Omsk Region, Omsk (E.K.), and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) \u2014 both in Russia; Norton Cancer Institute, Louisville, KY (C.H.P.); La Unidad de Gesti\u00f3n Cl\u00ednica Intercentros de Oncolog\u00eda M\u00e9dica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga, Malaga (A.M.-P.), and Maimonides Institute for Biomedical Research of C\u00f3..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Joensuu","sequence":"additional","affiliation":[{"name":"From the Massachusetts General Hospital Cancer Center and Harvard Medical School \u2014 both in Boston (M.R.S.); the Robert H. 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