{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:15:22Z","timestamp":1787933722054,"version":"build-2784847793"},"reference-count":20,"publisher":"Massachusetts Medical Society","issue":"19","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100004571","name":"Programme Hospitalier de Recherche Clinique from the French Ministry of health","doi-asserted-by":"publisher","award":["PHRC-14-0058"],"award-info":[{"award-number":["PHRC-14-0058"]}],"id":[{"id":"10.13039\/501100004571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2023,11,9]]},"DOI":"10.1056\/nejmoa2304192","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T22:01:11Z","timestamp":1699480871000},"page":"1753-1765","source":"Crossref","is-referenced-by-count":27,"title":["Trial of Botulinum Toxin for Isolated or Essential Head Tremor"],"prefix":"10.1056","volume":"389","author":[{"given":"Ana","family":"Marques","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Simonetta-Moreau","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Castelnovo","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"De Verdal","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Fluch\u00e8re","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Laurencin","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5644-1292","authenticated-orcid":false,"given":"Bertrand","family":"Degos","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Tir","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Kreisler","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Blanchet-Fourcade","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Guehl","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Colin","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelia","family":"Poujois","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Sangla","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Tatu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Derost","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Gayraud","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Tranchant","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Amarantini","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Devos","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rascol","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Corvol","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Durif","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Rieu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Universit\u00e9 Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neurosciences and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, INSERM, Universit\u00e9 Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, N\u00eemes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Universit\u00e9, Marseille (F.F.), Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unit\u00e9 1028, CNRS, Unit\u00e9 Mixte de Recherche ..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4485"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(11)70044-X"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27121"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-022-01185-8"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.822"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120516"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.8.1185"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14030203"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27700"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.11.002"},{"key":"e_1_3_5_12_2","first-page":"225","volume-title":"Parkinson\u2019s disease and movement disorders","author":"Fahn S","year":"1993","unstructured":"Fahn S, Tolosa E, Marin S. Clinical rating scale for tremor. In: Jankovic J, ed. Parkinson\u2019s disease and movement disorders. Baltimore: Williams & Wilkins, 1993:225-234."},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21412"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92070-2"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2967-x"},{"key":"e_1_3_5_16_2","first-page":"28","article-title":"The Clinical Global Impressions Scale: applying a research tool in clinical practice.","volume":"4","author":"Busner J","year":"2007","unstructured":"Busner J, Targum SD. The Clinical Global Impressions Scale: applying a research tool in clinical practice. Psychiatry (Edgmont) 2007;4:28-37.20526405","journal-title":"Psychiatry (Edgmont)"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.05.009"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2023.03.030"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.08.017"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/s22062385"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-10995-2"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2304192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T22:48:54Z","timestamp":1749682134000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2304192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":20,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2023,11,9]]}},"alternative-id":["10.1056\/NEJMoa2304192"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2304192","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]}}}