{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:57:48Z","timestamp":1792454268417,"version":"4.5.0"},"reference-count":43,"publisher":"Massachusetts Medical Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2023,8,17]]},"DOI":"10.1056\/nejmoa2304194","type":"journal-article","created":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T08:00:11Z","timestamp":1685865611000},"page":"589-601","source":"Crossref","is-referenced-by-count":821,"title":["Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma"],"prefix":"10.1056","volume":"389","author":[{"given":"Ingo K.","family":"Mellinghoff","sequence":"first","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"van den Bent","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah T.","family":"Blumenthal","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Touat","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine B.","family":"Peters","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Clarke","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Mendez","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Yust-Katz","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Welsh","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren P.","family":"Mason","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Ducray","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshie","family":"Umemura","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burt","family":"Nabors","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Holdhoff","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas F.","family":"Hottinger","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Arakawa","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Sepulveda","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wick","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Soffietti","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Perry","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); the Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (M.J.B.); Tel Aviv Medical Center, Tel Aviv University, Tel Aviv (D.T.B., S.Y.-K.), and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) \u2014 both in Israel; Sorbonne Universit\u00e9, Institut du Cerveau, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires la Piti\u00e9 Salp\u00eatri\u00e8re\u2013Charles Foix, Paris (M.T.), and H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon (F.D.) \u2014 both in France; Duke University Medical Center, Durham, NC (K.B.P.); the University of California, San Francisco, San Francisco (J.C.); Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.); the Royal Marsden Hospital, London (L.W.); Princess Margaret Cancer Centre (W.P.M.), and Sunnybrook Health Sciences Centre (J.R.P.), University of Toronto (W.P.M.) \u2014 both in Toronto; the University of Michigan C..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Giglio","sequence":"additional","affiliation":[{"name":"From Memorial Sloan Kettering Cancer Center, New York (I.K.M.); 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