{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T05:03:12Z","timestamp":1794459792399,"version":"4.9.1"},"reference-count":22,"publisher":"Massachusetts Medical Society","issue":"20","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P2BSP3-181720"],"award-info":[{"award-number":["P2BSP3-181720"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNF-162608"],"award-info":[{"award-number":["SNF-162608"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008485","name":"Schweizerische Akademie der Medizinischen Wissenschaften","doi-asserted-by":"publisher","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/501100008485","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["FAPEMIG-APQ-01521-21"],"award-info":[{"award-number":["FAPEMIG-APQ-01521-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","award":["Copeptin measurement"],"award-info":[{"award-number":["Copeptin measurement"]}],"id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2023,11,16]]},"DOI":"10.1056\/nejmoa2306263","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T22:01:19Z","timestamp":1700085679000},"page":"1877-1887","source":"Crossref","is-referenced-by-count":69,"title":["Arginine or Hypertonic Saline\u2013Stimulated Copeptin to Diagnose AVP Deficiency"],"prefix":"10.1056","volume":"389","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-4685","authenticated-orcid":false,"given":"Julie","family":"Refardt","sequence":"first","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-7304","authenticated-orcid":false,"given":"Cihan","family":"Atila","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Chifu","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Ferrante","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6953-9133","authenticated-orcid":false,"given":"Zoran","family":"Erlic","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana B.","family":"Drummond","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Indirli","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosmarijn C.","family":"Drexhage","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-8191","authenticated-orcid":false,"given":"Clara O.","family":"Sailer","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Widmer","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Felder","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Powlson","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Hutter","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah R.","family":"Vogt","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gurnell","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz S.","family":"Soares","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Hofland","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-6398","authenticated-orcid":false,"given":"Martin","family":"Fassnacht","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-2700","authenticated-orcid":false,"given":"Bettina","family":"Winzeler","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Christ-Crain","sequence":"additional","affiliation":[{"name":"From the Departments of Endocrinology, Diabetology, and Metabolism (J.R., C.A., C.O.S., A.W., S.F., N.H., B.W., M.C.-C.) and Clinical Research (J.R., C.A., C.O.S., A.W., S.F., N.H., D.R.V., B.W., M.C.-C.), University Hospital Basel, University of Basel, Basel, and the Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich and University of Zurich (Z.E., F.B.), and the LOOP Zurich\u2013Medical Research Center (F.B.), Zurich \u2014 all in Switzerland; the Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands (J.R., R.C.D., J.H.); the Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of W\u00fcrzburg (I.C., M.F.), and Central Laboratory, University Hospital W\u00fcrzburg (M.F.), W\u00fcrzburg, and Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich (F.B.) \u2014 all in Germany; the Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Os..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13261"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-22-0751"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0103-2"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.89"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-5-721"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803760"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2345"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060038"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2016.02.003"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112243052601"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4507"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080895"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31255-3"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-8194.2004.01183.x"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-021-01175-y"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<891::AID-SIM780>3.0.CO;2-B"},{"key":"e_1_3_5_18_2","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2021","unstructured":"R Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing, 2021."},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14880"},{"issue":"5","key":"e_1_3_5_20_2","first-page":"R671","article-title":"Osmoregulation and control of vasopressin secretion in healthy humans.","volume":"253","author":"Baylis PH","year":"1987","unstructured":"Baylis PH. Osmoregulation and control of vasopressin secretion in healthy humans. Am J Physiol 1987;253(5):R671-R678.3318505","journal-title":"Am J Physiol"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14417"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-22-0400"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1530\/EC-22-0504"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2306263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T22:48:35Z","timestamp":1749682115000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2306263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,16]]},"references-count":22,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2023,11,16]]}},"alternative-id":["10.1056\/NEJMoa2306263"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2306263","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,16]]}}}