{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:21:24Z","timestamp":1792178484566,"version":"4.4.0"},"reference-count":24,"publisher":"Massachusetts Medical Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2025,2,13]]},"DOI":"10.1056\/nejmoa2309728","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T17:00:46Z","timestamp":1739379646000},"page":"677-685","source":"Crossref","is-referenced-by-count":70,"title":["CAR+ T-Cell Lymphoma after Cilta-cel Therapy for Relapsed or Refractory Myeloma"],"prefix":"10.1056","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-6582","authenticated-orcid":false,"given":"Simon J.","family":"Harrison","sequence":"first","affiliation":[{"name":"Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Royal Melbourne Hospital, Melbourne, VIC, Australia"},{"name":"Translation Laboratory, Centre of Excellence in Cellular Immunotherapy, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Touzeau","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Centre Hospitalier Universitaire (CHU) H\u00f4tel Dieu, Nantes, France"},{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, INSERM, Centre National de la Recherche Scientifique, Universit\u00e9 d\u2019Angers, Universit\u00e9 de Nantes, Nantes, France"},{"name":"Site de Recherche Int\u00e9gr\u00e9e sur le Cancer, Imaging and Longitudinal Investigations to Ameliorate Decision-making (ILIAD), French National Cancer Institute\u2013French Ministry of Health\u2013INSERM 12558, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Kint","sequence":"additional","affiliation":[{"name":"Dienst Klinische Hematologie, Universitair Ziekenhuis Gent, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Li","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamia","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Mayeur-Rousse","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019H\u00e9matologie, CHU H\u00f4tel Dieu, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Rahman","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Royal Melbourne Hospital, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Le Bris","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, INSERM, Centre National de la Recherche Scientifique, Universit\u00e9 d\u2019Angers, Universit\u00e9 de Nantes, Nantes, France"},{"name":"Site de Recherche Int\u00e9gr\u00e9e sur le Cancer, Imaging and Longitudinal Investigations to Ameliorate Decision-making (ILIAD), French National Cancer Institute\u2013French Ministry of Health\u2013INSERM 12558, Nantes, France"},{"name":"Laboratoire d\u2019H\u00e9matologie, CHU H\u00f4tel Dieu, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Er","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Royal Melbourne Hospital, Melbourne, VIC, Australia"},{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Eugene-Lamer","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Anatomo-Pathologie, CHU, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Haynes","sequence":"additional","affiliation":[{"name":"Translation Laboratory, Centre of Excellence in Cellular Immunotherapy, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Li","sequence":"additional","affiliation":[{"name":"Translation Laboratory, Centre of Excellence in Cellular Immunotherapy, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Translation Laboratory, Centre of Excellence in Cellular Immunotherapy, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bodet-Milin","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, INSERM, Centre National de la Recherche Scientifique, Universit\u00e9 d\u2019Angers, Universit\u00e9 de Nantes, Nantes, France"},{"name":"Site de Recherche Int\u00e9gr\u00e9e sur le Cancer, Imaging and Longitudinal Investigations to Ameliorate Decision-making (ILIAD), French National Cancer Institute\u2013French Ministry of Health\u2013INSERM 12558, Nantes, France"},{"name":"Service de M\u00e9decine Nucl\u00e9aire, CHU, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Moreau","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Anatomo-Pathologie, CHU, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Letouz\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, INSERM, Centre National de la Recherche Scientifique, Universit\u00e9 d\u2019Angers, Universit\u00e9 de Nantes, Nantes, France"},{"name":"Site de Recherche Int\u00e9gr\u00e9e sur le Cancer, Imaging and Longitudinal Investigations to Ameliorate Decision-making (ILIAD), French National Cancer Institute\u2013French Ministry of Health\u2013INSERM 12558, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoletta","family":"Lendvai","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan M.","family":"Schecter","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Deraedt","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnob","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Lengil","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Vogel","sequence":"additional","affiliation":[{"name":"Johnson & Johnson\u2013Cilag, Neuss, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Foulk","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Smirnov","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Slaughter","sequence":"additional","affiliation":[{"name":"Cilag International, Zug, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Lonardi","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Lee","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Titusville, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreta","family":"Marquez","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayah","family":"Sankari","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, High Wycombe, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Plaks","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Octavio Costa","family":"Filho","sequence":"additional","affiliation":[{"name":"Legend Biotech USA, Somerset, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Patel","sequence":"additional","affiliation":[{"name":"Legend Biotech USA, Somerset, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Geng","sequence":"additional","affiliation":[{"name":"Legend Biotech USA, Somerset, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gastinne","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Centre Hospitalier Universitaire (CHU) H\u00f4tel Dieu, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Kelly","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Royal Melbourne Hospital, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-4343","authenticated-orcid":false,"given":"Ing Soo","family":"Tiong","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Royal Melbourne Hospital, Melbourne, VIC, Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Eveillard","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, INSERM, Centre National de la Recherche Scientifique, Universit\u00e9 d\u2019Angers, Universit\u00e9 de Nantes, Nantes, France"},{"name":"Site de Recherche Int\u00e9gr\u00e9e sur le Cancer, Imaging and Longitudinal Investigations to Ameliorate Decision-making (ILIAD), French National Cancer Institute\u2013French Ministry of Health\u2013INSERM 12558, Nantes, France"},{"name":"Laboratoire d\u2019H\u00e9matologie, CHU H\u00f4tel Dieu, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Chevallier","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Centre Hospitalier Universitaire (CHU) H\u00f4tel Dieu, Nantes, France"},{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, INSERM, Centre National de la Recherche Scientifique, Universit\u00e9 d\u2019Angers, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lade","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Royal Melbourne Hospital, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Moreau","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Centre Hospitalier Universitaire (CHU) H\u00f4tel Dieu, Nantes, France"},{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, INSERM, Centre National de la Recherche Scientifique, Universit\u00e9 d\u2019Angers, Universit\u00e9 de Nantes, Nantes, France"},{"name":"Site de Recherche Int\u00e9gr\u00e9e sur le Cancer, Imaging and Longitudinal Investigations to Ameliorate Decision-making (ILIAD), French National Cancer Institute\u2013French Ministry of Health\u2013INSERM 12558, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Grimmond","sequence":"additional","affiliation":[{"name":"Collaborative Center for Genomic Cancer Medicine, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Oliaro","sequence":"additional","affiliation":[{"name":"Translation Laboratory, Centre of Excellence in Cellular Immunotherapy, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Tessoulin","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Centre Hospitalier Universitaire (CHU) H\u00f4tel Dieu, Nantes, France"},{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, INSERM, Centre National de la Recherche Scientifique, Universit\u00e9 d\u2019Angers, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piers","family":"Blombery","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"},{"name":"Royal Melbourne Hospital, Melbourne, VIC, Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"},{"name":"Collaborative Center for Genomic Cancer Medicine, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","unstructured":"Food and Drug Administration. FDA investigating serious risk of T-cell malignancy following BCMA-directed or CD19-directed autologous chimeric antigen receptor (CAR) T cell immunotherapies. November 28 2023 (https:\/\/www.fda.gov\/vaccines-blood-biologics\/safety-availability-biologics\/fda-investigating-serious-risk-t-cell-malignancy-following-bcma-directed-or-cd19-directed-autologous)."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2400209"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303379"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01578-0"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2020.100757"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194919"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.12.5324-5331.2004"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0361"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-170797"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900959"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020626"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.158428"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408542"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05692-z"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408617"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0028"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.146118"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.026"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.816005"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2401530"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021010858"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-10787-5"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2309728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T18:32:27Z","timestamp":1749666747000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2309728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,2,13]]}},"alternative-id":["10.1056\/NEJMoa2309728"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2309728","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]}}}