{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:06:56Z","timestamp":1792206416503,"version":"4.4.0"},"reference-count":28,"publisher":"Massachusetts Medical Society","issue":"17","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","award":["Funded by Takeda Development Center Americas, Inc."],"award-info":[{"award-number":["Funded by Takeda Development Center Americas, Inc."]}],"id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2024,5,2]]},"DOI":"10.1056\/nejmoa2314793","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T21:00:27Z","timestamp":1714597227000},"page":"1584-1596","source":"Crossref","is-referenced-by-count":111,"title":["Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura"],"prefix":"10.1056","volume":"390","author":[{"given":"Marie","family":"Scully","sequence":"first","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Antun","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spero R.","family":"Cataland","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Coppo","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dossier","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Biebuyck","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf-Achim","family":"Hassenpflug","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Kentouche","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kn\u00f6bl","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna A.","family":"Kremer Hovinga","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Fernanda","family":"L\u00f3pez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Ortel","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Windyga","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indranil","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cronin","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Mellg\u00e5rd","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munjal","family":"Patel","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; the Department of Medicine 1, Division of Hematology and Hemostasis..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Patwari","sequence":"additional","affiliation":[{"name":"From the Department of Haematology, University College London Hospitals, London (M.S.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta (A.A.); the Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); the Department of Hematology and National Reference Center for Thrombotic Microangiopathies, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) and Sorbonne Universit\u00e9 (P.C.), the Department of Pediatric Nephrology, Robert Debr\u00e9 Hospital, AP-HP and University of Paris (C.D.), and the Department of Pediatric Nephrology, H\u00f4pital Universitaire Necker\u2013Enfants Malades, AP-HP (N.B.) \u2014 all in Paris; the Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (W.-A.H.), and the Section of Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Jena, Jena (K.K.) \u2014 both in Germany; 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