{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:24:21Z","timestamp":1792268661423,"version":"4.4.0"},"reference-count":31,"publisher":"Massachusetts Medical Society","issue":"20","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100014941","name":"Cytokinetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2024,5,30]]},"DOI":"10.1056\/nejmoa2401424","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:21:16Z","timestamp":1715592076000},"page":"1849-1861","source":"Crossref","is-referenced-by-count":339,"title":["Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy"],"prefix":"10.1056","volume":"390","author":[{"given":"Martin S.","family":"Maron","sequence":"first","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Masri","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Nassif","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Barriales-Villa","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Arad","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Cardim","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Choudhury","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Claggett","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Coats","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Dirk","family":"D\u00fcngen","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garcia-Pavia","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert A.","family":"Hag\u00e8ge","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Januzzi","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Lewis","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Sheng","family":"Ma","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Michels","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Oreziak","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali T.","family":"Owens","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Tfelt-Hansen","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"van Sinttruije","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Veselka","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Watkins","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Jacoby","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Heitner","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Kupfer","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady I.","family":"Malik","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Meng","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Wohltman","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore P.","family":"Abraham","sequence":"additional","affiliation":[{"name":"From Lahey Hospital and Medical Center, Burlington (M.S.M.), and the Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School (B.C., S.D.S.), the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School (J.L.J., G.D.L.), and the Baim Institute for Clinical Research (J.L.J.), Boston \u2014 all in Massachusetts; Oregon Health and Science University, Portland (A.M.); the University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke\u2019s Mid America Heart Institute, Kansas City (M.E.N., J.A.S.); Complejo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovaculares (CIBERCV)\u2013Instituto de Salud Carlos III, A Coru\u00f1a (R.B.-V.), and Hospital Universitario Puerta de Hierro de Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2013Segovia de Arana, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.079"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1710575"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.03.004"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.10.020"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.045"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.053527"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.002248"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033200"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.067"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00682-0"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021332"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00830-5"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.02.032"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.0252"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005152"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.02.024"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa282"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000122"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad637"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.04.048"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31792-X"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01290"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.04.008"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26630-z"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.10.020"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.10.004"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.2.580"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.004"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2022.03.002"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.965186"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2401424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T18:43:32Z","timestamp":1749667412000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2401424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":31,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2024,5,30]]}},"alternative-id":["10.1056\/NEJMoa2401424"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2401424","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,30]]}}}