{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:10:56Z","timestamp":1792293056163,"version":"4.4.0"},"reference-count":42,"publisher":"Massachusetts Medical Society","issue":"21","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2025,6,5]]},"DOI":"10.1056\/nejmoa2413258","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T21:02:28Z","timestamp":1746046948000},"page":"2089-2099","source":"Crossref","is-referenced-by-count":1142,"title":["Phase 3 Trial of Semaglutide in Metabolic Dysfunction\u2013Associated Steatohepatitis"],"prefix":"10.1056","volume":"392","author":[{"given":"Arun J.","family":"Sanyal","sequence":"first","affiliation":[{"name":"Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, Virginia Commonwealth University School of Medicine, Richmond"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Newsome","sequence":"additional","affiliation":[{"name":"Roger Williams Institute of Liver Studies, Faculty of Life Sciences and Medicine, King\u2019s College London, Foundation for Liver Research and King\u2019s College Hospital, London"},{"name":"College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kliers","sequence":"additional","affiliation":[{"name":"Novo Nordisk, Bagsv\u00e6rd, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Harms","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Novo Nordisk, Bagsv\u00e6rd, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle T.","family":"Long","sequence":"additional","affiliation":[{"name":"Novo Nordisk, Bagsv\u00e6rd, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-4077","authenticated-orcid":false,"given":"Mette Skalsh\u00f8i","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Novo Nordisk, Bagsv\u00e6rd, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.G.","family":"Cali","sequence":"additional","affiliation":[{"name":"Novo Nordisk, Bagsv\u00e6rd, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Bugianesi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Rinella","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, Faculty of Medicine, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"},{"name":"Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"},{"name":"German Center for Diabetes Research, Partner D\u00fcsseldorf, Munich-Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Ratziu","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institute for Cardiometabolism and Nutrition, H\u00f4pital Piti\u00e9\u2013Salp\u00eatri\u00e8re, INSERM Unit\u00e9 Mixte de Recherche Scientifique 1138 Centre de Recherche des Cordeliers, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31599"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.043"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.12565"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029349"},{"key":"e_1_3_5_8_2","unstructured":"Ozempic. Bagsv\u00e6rd Denmark: Novo Nordisk 2017 (package insert) (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/209637lbl.pdf)."},{"key":"e_1_3_5_9_2","unstructured":"Wegovy. Bagsv\u00e6rd Denmark: Novo Nordisk 2021. (package insert) (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/215256s000lbl.pdf)."},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03015-5"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028395"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309000"},{"key":"e_1_3_5_15_2","unstructured":"Food and Drug Administration. FDA approves first treatment for patients with liver scarring due to fatty liver disease. March 14 2024 (https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-treatment-patients-liver-scarring-due-fatty-liver-disease)."},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.04.002"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03223-z"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18331"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.030"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.014"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530643"},{"key":"e_1_3_5_23_2","first-page":"1323","article-title":"On the variance estimator for the Mantel-Haenszel risk difference.","volume":"45","author":"Sato T","year":"1989","unstructured":"Sato T, Greenland S, Robins JM. On the variance estimator for the Mantel-Haenszel risk difference. Biometrics 1989;45:1323-1324.","journal-title":"Biometrics"},{"key":"e_1_3_5_24_2","doi-asserted-by":"crossref","unstructured":"Jennison C Turnbull B. Group sequential methods with applications to clinical trials. New York: Chapman and Hall 1999.","DOI":"10.1201\/9780367805326"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3495"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.1999.01188.x"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201700231"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/10543406.2021.1979574"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.036"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.1447"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.02.024"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1732354"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00448-y"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13955"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00213-0"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.07.033"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.2337\/dsi23-0013"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00068-7"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06196-3"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000323"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2022.102427"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2413258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:21:39Z","timestamp":1767972099000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2413258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":42,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,6,5]]}},"alternative-id":["10.1056\/NEJMoa2413258"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2413258","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]}}}