{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:50:33Z","timestamp":1793994633985,"version":"4.8.0"},"reference-count":34,"publisher":"Massachusetts Medical Society","issue":"15","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"name":"RemeGen Co., Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2025,10,16]]},"DOI":"10.1056\/nejmoa2414719","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T21:00:27Z","timestamp":1760562027000},"page":"1475-1485","source":"Crossref","is-referenced-by-count":61,"title":["A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus"],"prefix":"10.1056","volume":"393","author":[{"given":"Ronald F.","family":"van Vollenhoven","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Amsterdam University Medical Center and Amsterdam Rheumatology Center, Amsterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan T.","family":"Merrill","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunde","family":"Bao","sequence":"additional","affiliation":[{"name":"Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Li","sequence":"additional","affiliation":[{"name":"Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankang","family":"Hu","sequence":"additional","affiliation":[{"name":"Pingxiang People\u2019s Hospital, Pingxiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghui","family":"Huang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jining No.1 People\u2019s Hospital, Jining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibo","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Hospital, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyou","family":"Mo","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guilin Medical University, Guilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2019ai","family":"Lu","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Li","sequence":"additional","affiliation":[{"name":"Zhuzhou Central Hospital, Zhuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Changhai Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"RemeGen, Rheumatology, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"RemeGen, Rheumatology, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zuraw","sequence":"additional","affiliation":[{"name":"RemeGen Biosciences, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Wang","sequence":"additional","affiliation":[{"name":"Binzhou Medical University Hospital, Binzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Fang","sequence":"additional","affiliation":[{"name":"RemeGen, Rheumatology, Yantai, China"},{"name":"School of Life Science and Technology, Tongji University, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100359"},{"key":"e_1_3_5_3_2","first-page":"330","article-title":"Manifestations of systemic lupus erythematosus.","volume":"6","author":"Cojocaru M","year":"2011","unstructured":"Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD. Manifestations of systemic lupus erythematosus. Maedica (Bucur) 2011;6:330-336.22879850","journal-title":"Maedica (Bucur)"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22894"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12660"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061965"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.11.7276"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.6.3655"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000218"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-005-4091-5"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315608254"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket120"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61354-2"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.30613"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2076"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.08.040"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2016.1276903"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.022491"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14613"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105704"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.686"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/09612033221141253"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.2022.J074"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224854"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051135"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh624"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep064"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211631"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3738"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205067"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40360"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab115"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(19)30076-1"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912196"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2414719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T21:00:41Z","timestamp":1760562041000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2414719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":34,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,10,16]]}},"alternative-id":["10.1056\/NEJMoa2414719"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2414719","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,16]]}}}