{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:42:36Z","timestamp":1787776956396,"version":"build-2784847793"},"reference-count":46,"publisher":"Massachusetts Medical Society","issue":"17","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"publisher","award":["Fonds Europ\u00e9en de D\u00e9veloppement R\u00e9gional"],"award-info":[{"award-number":["Fonds Europ\u00e9en de D\u00e9veloppement R\u00e9gional"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["AAPG 2020 \u201cSplicHypoxia\u201d"],"award-info":[{"award-number":["AAPG 2020 \u201cSplicHypoxia\u201d"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-LABX-0051"],"award-info":[{"award-number":["ANR-11-LABX-0051"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["PRTS 2015 \u201cGenRED\u201d"],"award-info":[{"award-number":["PRTS 2015 \u201cGenRED\u201d"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013920","name":"VHL Alliance USA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["MSCA-HYPOXIA project 101067746"],"award-info":[{"award-number":["MSCA-HYPOXIA project 101067746"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation project","doi-asserted-by":"publisher","award":["310030_207460"],"award-info":[{"award-number":["310030_207460"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017557","name":"Swiss National Centre of Competence in Research Kidney Control of Homeostasis","doi-asserted-by":"publisher","award":["grant number 183774"],"award-info":[{"award-number":["grant number 183774"]}],"id":[{"id":"10.13039\/501100017557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013414","name":"R\u00e9gion des Pays de la Loire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1056\/nejmoa2414954","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T01:02:46Z","timestamp":1746061366000},"page":"1684-1697","source":"Crossref","is-referenced-by-count":14,"title":["Identification of Hepatic-like EPO as a Cause of Polycythemia"],"prefix":"10.1056","volume":"392","author":[{"given":"Laurent","family":"Martin","sequence":"first","affiliation":[{"name":"Laboratoire Antidopage Fran\u00e7ais, Universit\u00e9 Paris-Saclay, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Maric","sequence":"additional","affiliation":[{"name":"Section of Medicine, Department of Endocrinology, Metabolism, and Cardiovascular System, University of Fribourg, Fribourg, Switzerland"},{"name":"National Center of Competence in Research Kidney Control of Homeostasis (Kidney.CH), Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salam","family":"Idriss","sequence":"additional","affiliation":[{"name":"\u00c9cole Pratique des Hautes \u00c9tudes, Paris Sciences et Lettres Universit\u00e9, Paris"},{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Delamare","sequence":"additional","affiliation":[{"name":"\u00c9cole Pratique des Hautes \u00c9tudes, Paris Sciences et Lettres Universit\u00e9, Paris"},{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Le Roy","sequence":"additional","affiliation":[{"name":"\u00c9cole Pratique des Hautes \u00c9tudes, Paris Sciences et Lettres Universit\u00e9, Paris"},{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Maaziz","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie Biologique, P\u00f4le Biologie, CHU de Dijon, Dijon, France"},{"name":"Fili\u00e8re de Sant\u00e9 des Maladies Constitutionnelles Rares du Globule Rouge et de l\u2019Erythropo\u00ef\u00e8se, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Caillaud","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Si-Tayeb","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Robriquet","sequence":"additional","affiliation":[{"name":"\u00c9cole Pratique des Hautes \u00c9tudes, Paris Sciences et Lettres Universit\u00e9, Paris"},{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Lenglet","sequence":"additional","affiliation":[{"name":"\u00c9cole Pratique des Hautes \u00c9tudes, Paris Sciences et Lettres Universit\u00e9, Paris"},{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Erceau","sequence":"additional","affiliation":[{"name":"\u00c9cole Pratique des Hautes \u00c9tudes, Paris Sciences et Lettres Universit\u00e9, Paris"},{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bellann\u00e9-Chantelot","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 Mixte de Recherche 1287, Villejuif, France"},{"name":"Gustave Roussy, Villejuif, France"},{"name":"D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5915-6910","authenticated-orcid":false,"given":"Isabelle","family":"Plo","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 Mixte de Recherche 1287, Villejuif, France"},{"name":"Gustave Roussy, Villejuif, France"},{"name":"Paris-Saclay University, INSERM Unit\u00e9 1287, Villejuif, France"},{"name":"France Intergroup des Syndromes My\u00e9loprolif\u00e9ratifs, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Aral","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie Biologique, P\u00f4le Biologie, CHU de Dijon, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Garrec","sequence":"additional","affiliation":[{"name":"Service de G\u00e9n\u00e9tique M\u00e9dicale, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Airaud","sequence":"additional","affiliation":[{"name":"Service de G\u00e9n\u00e9tique M\u00e9dicale, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Gianfermi","sequence":"additional","affiliation":[{"name":"Laboratoire Antidopage Fran\u00e7ais, Universit\u00e9 Paris-Saclay, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Antunes","sequence":"additional","affiliation":[{"name":"Section of Medicine, Department of Endocrinology, Metabolism, and Cardiovascular System, University of Fribourg, Fribourg, Switzerland"},{"name":"National Center of Competence in Research Kidney Control of Homeostasis (Kidney.CH), Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Keppner","sequence":"additional","affiliation":[{"name":"Section of Medicine, Department of Endocrinology, Metabolism, and Cardiovascular System, University of Fribourg, Fribourg, Switzerland"},{"name":"National Center of Competence in Research Kidney Control of Homeostasis (Kidney.CH), Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Mathilda","family":"Vincent","sequence":"additional","affiliation":[{"name":"Section of Medicine, Department of Endocrinology, Metabolism, and Cardiovascular System, University of Fribourg, Fribourg, Switzerland"},{"name":"National Center of Competence in Research Kidney Control of Homeostasis (Kidney.CH), Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Desfontaine","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Mod\u00e9","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Laporte","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gaignerie","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, BioCore, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Chariau","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, BioCore, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Leray","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, BioCore, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coline","family":"Rogue","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, BioCore, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"David","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, BioCore, Nantes, France"},{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Redon","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"B\u00e9zieau","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"},{"name":"Service de G\u00e9n\u00e9tique M\u00e9dicale, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamisse","family":"Mansour-Hendili","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie\u2013Biologie Mol\u00e9culaire, Pharmacologie, G\u00e9n\u00e9tique M\u00e9dicale, and Red Cell Disease Referral Center, Unit\u00e9 des Maladies G\u00e9n\u00e9tiques du Globule Rouge, Universit\u00e9 Paris-Est Cr\u00e9teil, AP-HP, H\u00f4pitaux Universitaires Henri Mondor, Creteil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, Mondor Institute for Biomedical Research Equipe Pirenne, Laboratoire d\u2019Excellence GR-Ex, Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Galact\u00e9ros","sequence":"additional","affiliation":[{"name":"Fili\u00e8re de Sant\u00e9 des Maladies Constitutionnelles Rares du Globule Rouge et de l\u2019Erythropo\u00ef\u00e8se, Cr\u00e9teil, France"},{"name":"D\u00e9partement de Biochimie\u2013Biologie Mol\u00e9culaire, Pharmacologie, G\u00e9n\u00e9tique M\u00e9dicale, and Red Cell Disease Referral Center, Unit\u00e9 des Maladies G\u00e9n\u00e9tiques du Globule Rouge, Universit\u00e9 Paris-Est Cr\u00e9teil, AP-HP, H\u00f4pitaux Universitaires Henri Mondor, Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Maillet","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, Centre Hospitalier de M\u00e2con, M\u00e2con, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Pasquet","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Immunology Child Hospital, University Hospital of Toulouse, Toulouse, France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Toulouse, Team Impact des Alt\u00e9rations G\u00e9n\u00e9tiques sur le D\u00e9veloppement des Leuc\u00e9mies Aigu\u00ebs, INSERM Unit\u00e9 1037, Institut Universitaire du Cancer de Toulouse\u2013Oncopole, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Cougoul","sequence":"additional","affiliation":[{"name":"Fili\u00e8re de Sant\u00e9 des Maladies Constitutionnelles Rares du Globule Rouge et de l\u2019Erythropo\u00ef\u00e8se, Cr\u00e9teil, France"},{"name":"Internal Medicine Department, Toulouse University Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Nloga","sequence":"additional","affiliation":[{"name":"H\u00e9matologie Clinique, H\u00f4pital Avicenne, AP-HP, H\u00f4pitaux Universitaires Paris Seine Saint-Denis, Bobigny, France"},{"name":"D\u00e9partement d\u2019Immunologie\u2013H\u00e9matologie, Universit\u00e9 de Paris and Sorbonne Paris Nord, Villetaneuse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Gardin","sequence":"additional","affiliation":[{"name":"H\u00e9matologie Clinique, H\u00f4pital Avicenne, AP-HP, H\u00f4pitaux Universitaires Paris Seine Saint-Denis, Bobigny, France"},{"name":"D\u00e9partement d\u2019Immunologie\u2013H\u00e9matologie, Universit\u00e9 de Paris and Sorbonne Paris Nord, Villetaneuse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Guitton","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, H\u00e9matologie B\u00e9nigne, H\u00f4pital Bic\u00eatre, Universit\u00e9 Paris-Saclay, Le Kremlin\u2013Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Dubruille","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, CHU Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vannina","family":"Giacobbi-Milet","sequence":"additional","affiliation":[{"name":"Onco-h\u00e9matologie P\u00e9diatrique, Centre Hospitalier du Mans, Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Leblanc","sequence":"additional","affiliation":[{"name":"Immuno-h\u00e9matologie P\u00e9diatrique, H\u00f4pital Robert-Debr\u00e9, Universit\u00e9 Paris-Cit\u00e9, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhre","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Semama","sequence":"additional","affiliation":[{"name":"R\u00e9animation N\u00e9onatale, Service de P\u00e9diatrie, CHU Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"James","sequence":"additional","affiliation":[{"name":"France Intergroup des Syndromes My\u00e9loprolif\u00e9ratifs, Paris"},{"name":"Laboratoire d\u2019H\u00e9matologie, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Carillo","sequence":"additional","affiliation":[{"name":"Laboratoire de Cytologie Clinique et Cytog\u00e9n\u00e9tique, Laboratoires de Biologie M\u00e9dicale de R\u00e9f\u00e9rence, N\u00e9oplasies My\u00e9loprolif\u00e9ratives, CHU Caremeau, Nimes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Ochmann","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, CHU Orl\u00e9ans, Orleans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Waage","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Research Department, St. Olav\u2019s Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Mortier","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, BioCore, Nantes, France"},{"name":"Nantes Universit\u00e9, CNRS, INSERM, Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, Nantes, France"},{"name":"Laboratoire d\u2019Excellence Immunotherapy\u2013Graft\u2013Oncology, Immuno-Onco-Greffe, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Maillasson","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, BioCore, Nantes, France"},{"name":"Nantes Universit\u00e9, CNRS, INSERM, Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, Nantes, France"},{"name":"Laboratoire d\u2019Excellence Immunotherapy\u2013Graft\u2013Oncology, Immuno-Onco-Greffe, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Qu\u00e9m\u00e9ner","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CNRS, INSERM, Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers, Nantes, France"},{"name":"Laboratoire d\u2019Excellence Immunotherapy\u2013Graft\u2013Oncology, Immuno-Onco-Greffe, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Cario","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany"},{"name":"Center for Rare Hematopoietic Disorders and Immunodeficiencies, Ulm University Medical Center, Ulm, Germany"},{"name":"German Center for Child and Adolescent Health partner site Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radek C.","family":"Skoda","sequence":"additional","affiliation":[{"name":"Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u00ebl","family":"Zermati","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine, Paris"},{"name":"Laboratoire d\u2019Excellence GR-Ex, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hoogewijs","sequence":"additional","affiliation":[{"name":"Section of Medicine, Department of Endocrinology, Metabolism, and Cardiovascular System, University of Fribourg, Fribourg, Switzerland"},{"name":"National Center of Competence in Research Kidney Control of Homeostasis (Kidney.CH), Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Marchand","sequence":"additional","affiliation":[{"name":"Laboratoire Antidopage Fran\u00e7ais, Universit\u00e9 Paris-Saclay, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Girodon","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie Biologique, P\u00f4le Biologie, CHU de Dijon, Dijon, France"},{"name":"Fili\u00e8re de Sant\u00e9 des Maladies Constitutionnelles Rares du Globule Rouge et de l\u2019Erythropo\u00ef\u00e8se, Cr\u00e9teil, France"},{"name":"France Intergroup des Syndromes My\u00e9loprolif\u00e9ratifs, Paris"},{"name":"Laboratoire d\u2019Excellence GR-Ex, Paris"},{"name":"INSERM Unit\u00e9 1231, Universit\u00e9 de Bourgogne, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Gardie","sequence":"additional","affiliation":[{"name":"\u00c9cole Pratique des Hautes \u00c9tudes, Paris Sciences et Lettres Universit\u00e9, Paris"},{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire (CHU) Nantes, Centre National de la Recherche Scientifique (CNRS), INSERM, l\u2019Institut du Thorax, Nantes, France"},{"name":"Fili\u00e8re de Sant\u00e9 des Maladies Constitutionnelles Rares du Globule Rouge et de l\u2019Erythropo\u00ef\u00e8se, Cr\u00e9teil, France"},{"name":"Laboratoire d\u2019Excellence GR-Ex, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3902"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110133"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.236406"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218131"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-270322"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.235.233"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.9.3218"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22448"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1019"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508423103"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.282913"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073123"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281698"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3304"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709064"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/dta.171"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.102707"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.062547"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23354"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2904"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1062"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1754"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbs017"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30117"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310404200"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68975-6"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V29.5.808.808"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180612"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","unstructured":"Dehnes Y Borgen M L\u00f6nnberg M Hemmersbach P. Shifted isoelectric profiles of endogenous erythropoietin possibly due to different physiological origin. In: Schanzer W Geyer H Gotzmann A Mareck U eds. Recent advances in doping analysis (16). Hellenthal Germany: Sportverlag Strauss 2008:359-362 (https:\/\/www.dshs-koeln.de\/fileadmin\/redaktion\/Institute\/Biochemie\/PDF\/Proceedings\/Proceedings_16\/16_pp_359-362.pdf).","DOI":"10.3724\/SP.J.1011.2008.00359"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.04.009"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.1.84.84"},{"key":"e_1_3_4_34_2","first-page":"169","article-title":"The asialoglycoprotein receptor: properties and modulation by ligand.","volume":"300","author":"Weiss P","year":"1989","unstructured":"Weiss P, Ashwell G. The asialoglycoprotein receptor: properties and modulation by ligand. Prog Clin Biol Res 1989;300:169-184.2674962","journal-title":"Prog Clin Biol Res"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510493200"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0265022"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.02813.x"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115652"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.145938"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70331-1"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200333040-00004"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1430"},{"key":"e_1_3_4_43_2","first-page":"5373","article-title":"Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements.","volume":"12","author":"Blanchard KL","year":"1992","unstructured":"Blanchard KL, Acquaviva AM, Galson DL, Bunn HF. Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol Cell Biol 1992;12:5373-5385.1448072","journal-title":"Mol Cell Biol"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.13.5680"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01081.x"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05463-11"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.08.043"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2414954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T01:03:24Z","timestamp":1746061404000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2414954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":46,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1056\/NEJMoa2414954"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2414954","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}