{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:48:03Z","timestamp":1793072883561,"version":"4.5.0"},"reference-count":19,"publisher":"Massachusetts Medical Society","issue":"8","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2025,8,21]]},"DOI":"10.1056\/nejmoa2502931","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:00:15Z","timestamp":1748851215000},"page":"741-752","source":"Crossref","is-referenced-by-count":270,"title":["Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer"],"prefix":"10.1056","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6925-6344","authenticated-orcid":false,"given":"Patrick M.","family":"Forde","sequence":"first","affiliation":[{"name":"Trinity St. James\u2019s Cancer Institute, Trinity College Dublin, Dublin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Spicer","sequence":"additional","affiliation":[{"name":"McGill University Health Centre, Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Provencio","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Mitsudomi","sequence":"additional","affiliation":[{"name":"Kindai University Faculty of Medicine, Ohno-Higashi, Osaka-Sayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Awad","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changli","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enriqueta","family":"Felip","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron Institute of Oncology, Universitat Aut\u00f2noma Barcelona, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"Brahmer","sequence":"additional","affiliation":[{"name":"Bloomberg\u2013Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Kerr","sequence":"additional","affiliation":[{"name":"Aberdeen Royal Infirmary, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis M.","family":"Taube","sequence":"additional","affiliation":[{"name":"Bloomberg\u2013Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor-Eliade","family":"Ciuleanu","sequence":"additional","affiliation":[{"name":"Institutul Oncologic Prof. Dr. Ion Chiricu\u0163\u0103 and University of Medicine and Pharmacy Iuliu Ha\u0163ieganu, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene B.","family":"Saylors","sequence":"additional","affiliation":[{"name":"Charleston Oncology, Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Neng","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Peking University Cancer Hospital and Institute, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Kanagawa Cancer Center, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moishe","family":"Liberman","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Martin","sequence":"additional","affiliation":[{"name":"Instituto Alexander Fleming, Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Broderick","sequence":"additional","affiliation":[{"name":"Bloomberg\u2013Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Wang","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Princeton, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junliang","family":"Cai","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Princeton, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quyen","family":"Duong","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Princeton, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Meadows-Shropshire","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Princeton, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Fiore","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Princeton, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeena","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Princeton, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Girard","sequence":"additional","affiliation":[{"name":"Institut du Thorax Curie-Montsouris, Institut Curie, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202170"},{"key":"e_1_3_5_3_2","unstructured":"Food and Drug Administration. Opdivo (nivolumab): highlights of prescribing information. 2025 (https:\/\/nctr-crs.fda.gov\/fdalabel\/services\/spl\/set-ids\/f570b9c4-6846-4de2-abfa-4d0a4ae4e394\/spl-doc)."},{"key":"e_1_3_5_4_2","unstructured":"European Medicines Agency. Opdivo (nivolumab): summary of product characteristics. 2024 (https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/opdivo-epar-product-information_en.pdf)."},{"key":"e_1_3_5_5_2","unstructured":"Health Canada. Opdivo: nivolumab for injection. Product monograph. 2024 (https:\/\/pdf.hres.ca\/dpd_pm\/00076152.PDF)."},{"key":"e_1_3_5_6_2","unstructured":"Bristol Myers Squibb. Instructions for Opdivo (nivolumab) injection. 2024. (In Chinese) (https:\/\/www.bms.com\/assets\/bms\/china\/restricted\/pi\/OPDIVO_20241029.pdf)."},{"key":"e_1_3_5_7_2","unstructured":"Pharmaceuticals and Medical Devices Agency. Opdivo (nivolumab). 2024 (package insert). (In Japanese) (https:\/\/www.pmda.go.jp\/PmdaSearch\/iyakuDetail\/ResultDataSetPDF\/180188_4291427A1024_1_66)."},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2215530"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2302983"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304875"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.24735"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2311926"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2024.09.069"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01756-2"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00498-4"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30453-8"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01224-2"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02660-6"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.11.008"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2024.09.014"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2502931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T21:00:43Z","timestamp":1755723643000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2502931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,21]]}},"alternative-id":["10.1056\/NEJMoa2502931"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2502931","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]}}}