{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:39:56Z","timestamp":1792118396689,"version":"4.4.0"},"reference-count":33,"publisher":"Massachusetts Medical Society","issue":"3","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2025,7,17]]},"DOI":"10.1056\/nejmoa2503701","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T08:00:38Z","timestamp":1748764838000},"page":"217-230","source":"Crossref","is-referenced-by-count":356,"title":["Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer"],"prefix":"10.1056","volume":"393","author":[{"given":"Yelena Y.","family":"Janjigian","sequence":"first","affiliation":[{"name":"Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah-Eddin","family":"Al-Batran","sequence":"additional","affiliation":[{"name":"Krankenhaus Nordwest, University Cancer Center (UCT) Frankfurt, and Frankfurt Institute of Clinical Cancer Research (IKF), Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zev A.","family":"Wainberg","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Muro","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Molena","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Van Cutsem","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\/Digestive Oncology, University Hospitals Leuven and KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Jin","family":"Hyung","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucjan","family":"Wyrwicz","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Youn","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, and the Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Omori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Moehler","sequence":"additional","affiliation":[{"name":"Research Center for Immunotherapy (FZI), Johannes Gutenberg-University Clinic, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Garrido","sequence":"additional","affiliation":[{"name":"Hemato-Oncology Department, SAGA Clinical Trial Center and Universidad Mayor, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulene C.S.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Clinical Oncology, Clinical Research Center, Northern Riograndense League Against Cancer, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moishe","family":"Liberman","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Centre de Recherche du CHUM, Montr\u00e9al"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2828-7325","authenticated-orcid":false,"given":"Victor Castro","family":"Oliden","sequence":"additional","affiliation":[{"name":"National Institute of Neoplastic Diseases (INEN), Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Stein","sequence":"additional","affiliation":[{"name":"Hematology-Oncology Practice Eppendorf (HOPE), University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Bilici","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Medical Oncology, Atat\u00fcrk University Faculty of Medicine, Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lorena","family":"Alvarenga","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Favaloro Foundation University Hospital, Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim","family":"Kozlov","sequence":"additional","affiliation":[{"name":"State Budgetary Health Care Institution, Novosibirsk Regional Clinical Oncology Dispensary, Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rivera","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-3748","authenticated-orcid":false,"given":"Akihito","family":"Kawazoe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Serrano","sequence":"additional","affiliation":[{"name":"Cytel, AstraZeneca, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Heilbron","sequence":"additional","affiliation":[{"name":"Oncology R&D, Late-Stage Development, AstraZeneca, Gaithersburg, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Negro","sequence":"additional","affiliation":[{"name":"Oncology R&D, Late-Stage Development, AstraZeneca, Gaithersburg, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Kurland","sequence":"additional","affiliation":[{"name":"Oncology R&D, Late-Stage Development, AstraZeneca, Gaithersburg, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Tabernero","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Vall d\u2019Hebron Hospital Campus and Institute of Oncology (VHIO), IOB-Quiron, UVic-UCC, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-016-1042-y"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.07.004"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32557-1"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-04636-y"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00797-2"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2408121"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2408154"},{"key":"e_1_3_5_10_2","unstructured":"Food and Drug Administration. Opdivo (nivolumab): highlights of prescribing information. 2023 (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/125554s128lbl.pdf)."},{"key":"e_1_3_5_11_2","unstructured":"Food and Drug Administration. Keytruda (pembrolizumab): highlights of prescribing information. 2024 (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/125514s147lbl.pdf)."},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00544-6"},{"key":"e_1_3_5_13_2","unstructured":"Food and Drug Administration. FDA approves durvalumab for extensive-stage small cell lung cancer. 2020 (https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-approves-durvalumab-extensive-stage-small-cell-lung-cancer)."},{"key":"e_1_3_5_14_2","unstructured":"Food and Drug Administration. FDA approves neoadjuvant\/adjuvant durvalumab for resectable non-small cell lung cancer. 2024 (https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-approves-neoadjuvantadjuvant-durvalumab-resectable-non-small-cell-lung-cancer)."},{"key":"e_1_3_5_15_2","unstructured":"Food and Drug Administration. FDA approves tremelimumab in combination with durvalumab for unresectable hepatocellular carcinoma. 2022 (https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-approves-tremelimumab-combination-durvalumab-unresectable-hepatocellular-carcinoma)."},{"key":"e_1_3_5_16_2","unstructured":"Food and Drug Administration. FDA approves durvalumab with chemotherapy for mismatch repair deficient primary advanced or recurrent endometrial cancer. 2024 (https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-approves-durvalumab-chemotherapy-mismatch-repair-deficient-primary-advanced-or-recurrent)."},{"key":"e_1_3_5_17_2","unstructured":"Food and Drug Administration. FDA approves durvalumab for muscle invasive bladder cancer. 2025 (https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-approves-durvalumab-muscle-invasive-bladder-cancer)."},{"key":"e_1_3_5_18_2","volume-title":"ed. AJCC cancer staging manual. 8th ed","author":"Amin MB","year":"2018","unstructured":"Amin MB, ed. AJCC cancer staging manual. 8th ed. Chicago: American College of Surgeons, 2018."},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2022-0093"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-023-01318-8"},{"key":"e_1_3_5_21_2","unstructured":"College of American Pathologists. Protocol for the examination of specimens from patients with carcinoma of the stomach. 2020 (https:\/\/documents.cap.org\/protocols\/cp-giupper-stomach-20-4100.pdf)."},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112088"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.08.2300"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2409408"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00541-7"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)33189-1"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmogo.2024.100050"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00676-4"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02167"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2023.102226"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-2920"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2020.100036"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.4000"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0191"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2503701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T21:00:30Z","timestamp":1752699630000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2503701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7,17]]}},"alternative-id":["10.1056\/NEJMoa2503701"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2503701","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]}}}