{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:56:11Z","timestamp":1792691771904,"version":"4.5.0"},"reference-count":33,"publisher":"Massachusetts Medical Society","issue":"18","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson & Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2025,11,6]]},"DOI":"10.1056\/nejmoa2504187","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T22:00:21Z","timestamp":1762380021000},"page":"1784-1795","source":"Crossref","is-referenced-by-count":39,"title":["Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents"],"prefix":"10.1056","volume":"393","author":[{"given":"Robert","family":"Bissonnette","sequence":"first","affiliation":[{"name":"Innovaderm Research, Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Soung","sequence":"additional","affiliation":[{"name":"Southern California Dermatology, Santa Ana"},{"name":"Harbor\u2013UCLA Medical Center, Torrance, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelaide A.","family":"Hebert","sequence":"additional","affiliation":[{"name":"UTHealth McGovern Medical School, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Pink","sequence":"additional","affiliation":[{"name":"St. John\u2019s Institute of Dermatology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust and King\u2019s College London, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pinter","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Frankfurt am Main, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Y.","family":"Moore","sequence":"additional","affiliation":[{"name":"Baylor University Medical Center, Dallas"},{"name":"University of North Texas Health Sciences Center, Texas College of Osteopathic Medicine, Fort Worth"},{"name":"Texas Christian University School of Medicine, Fort Worth"},{"name":"University of Texas Medical Branch at Galveston, Galveston"},{"name":"Arlington Center for Dermatology, Arlington Research Center, Arlington, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai"},{"name":"Institute of Psoriasis, Tongji University School of Medicine, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University, Third Hospital Haidian District, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl P.","family":"Toth","sequence":"additional","affiliation":[{"name":"Probity Medical Research and XLR8 Medical Research, Windsor, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Miller-Kassamali","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cafone","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Milpitas, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.C.","family":"DeKlotz","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Nunes","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Lebwohl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jan.13818"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.36469\/9817"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16746"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4029"},{"key":"e_1_3_5_7_2","first-page":"CD011535","article-title":"Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.","volume":"7","author":"Sbidian E","year":"2023","unstructured":"Sbidian E, Chaimani A, Guelimi R, et al. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database Syst Rev 2023;7:CD011535-CD011535.37436070","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-023-01034-7"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad252"},{"key":"e_1_3_5_10_2","unstructured":"Sotyktu (deucravacitinib). Dublin: Bristol Myers Squibb 2022 (package insert) https:\/\/packageinserts.bms.com\/pi\/pi_sotyktu.pdf)."},{"key":"e_1_3_5_11_2","unstructured":"Otezla (apremilast). Thousand Oaks CA: Amgen 2025 (package insert) (https:\/\/www.pi.amgen.com\/-\/media\/Project\/Amgen\/Repository\/pi-amgen-com\/Otezla\/otezla_pi_english.pdf)."},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-024-00668-0"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-67371-5"},{"key":"e_1_3_5_14_2","unstructured":"Stelara (ustekinumab). Horsham PA: Janssen Biotech 2025 (package insert) https:\/\/www.janssenlabels.com\/package-insert\/product-monograph\/prescribing-information\/STELARA-pi.pdf)."},{"key":"e_1_3_5_15_2","unstructured":"Tremfya (guselkumab). Horsham PA: Janssen Biotech 2025 (package insert) https:\/\/www.janssenlabels.com\/package-insert\/product-monograph\/prescribing-information\/TREMFYA-pi.pdf)."},{"key":"e_1_3_5_16_2","unstructured":"Skyrizi (risankizumab-rzaa). North Chicago IL: AbbVie 2025 (package insert) (https:\/\/www.rxabbvie.com\/pdf\/skyrizi_pi.pdf)."},{"key":"e_1_3_5_17_2","unstructured":"Ilumya (tildrakizumab-asmn). Cranbury NJ: Sun Pharmaceutical Industries 2024 (package insert) (https:\/\/www.ilumyapro.com\/content\/dam\/ilumya-pro\/Sun-Pharma_ILUMYA_US_Prescribing-Info-and-Medication-Guide_combined.pdf)."},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1331217"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308713"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.10.076"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2500155"},{"key":"e_1_3_5_22_2","doi-asserted-by":"crossref","unstructured":"Knight B Tammara B Modi NB et al. Translational pharmacokinetics of icotrokinra a targeted oral peptide that selectively blocks interleukin-23 receptor and inhibits signaling. Dermatol Ther (Heidelb) 2025;15:2495-2520.40629250.","DOI":"10.1007\/s13555-025-01454-7"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.865009"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000250839"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdds.2015.07.004"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2059051"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.042"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.041"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31713-6"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60726-6"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60725-4"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31279-5"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01576-4"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2504187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:59:42Z","timestamp":1769637582000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2504187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":33,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,11,6]]}},"alternative-id":["10.1056\/NEJMoa2504187"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2504187","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]}}}