{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T05:31:10Z","timestamp":1792992670218,"version":"4.5.0"},"reference-count":30,"publisher":"Massachusetts Medical Society","issue":"20","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100004690","name":"Minist\u00e8re de la Sant\u00e9","doi-asserted-by":"publisher","award":["PHRC16-0549\/HAO16012"],"award-info":[{"award-number":["PHRC16-0549\/HAO16012"]}],"id":[{"id":"10.13039\/501100004690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-RHU-0004"],"award-info":[{"award-number":["ANR-15-RHU-0004"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2025,11,20]]},"DOI":"10.1056\/nejmoa2508157","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:00:14Z","timestamp":1756458014000},"page":"1990-2000","source":"Crossref","is-referenced-by-count":38,"title":["Reduction of Antihypertensive Treatment in Nursing Home Residents"],"prefix":"10.1056","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5197-1515","authenticated-orcid":false,"given":"Athanase","family":"Benetos","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre Hospitalier R\u00e9gional Universitaire (CHRU) Nancy, P\u00f4le \u201cMaladies du Vieillissement, G\u00e9rontologie et Soins Palliatifs,\u201d Nancy, France"},{"name":"Universit\u00e9 de Lorraine, INSERM, D\u00e9faillance Cardio-Vasculaire Aig\u00fce et Chronique, and French Clinical Research Infrastructure Network\u2013Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Gautier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre Hospitalier R\u00e9gional Universitaire (CHRU) Nancy, P\u00f4le \u201cMaladies du Vieillissement, G\u00e9rontologie et Soins Palliatifs,\u201d Nancy, France"},{"name":"Universit\u00e9 de Lorraine, INSERM, D\u00e9faillance Cardio-Vasculaire Aig\u00fce et Chronique, and French Clinical Research Infrastructure Network\u2013Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Freminet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre Hospitalier R\u00e9gional Universitaire (CHRU) Nancy, P\u00f4le \u201cMaladies du Vieillissement, G\u00e9rontologie et Soins Palliatifs,\u201d Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Metz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre Hospitalier R\u00e9gional Universitaire (CHRU) Nancy, P\u00f4le \u201cMaladies du Vieillissement, G\u00e9rontologie et Soins Palliatifs,\u201d Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Labat","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM, D\u00e9faillance Cardio-Vasculaire Aig\u00fce et Chronique, and French Clinical Research Infrastructure Network\u2013Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Georgiopoulos","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre Hospitalier R\u00e9gional Universitaire (CHRU) Nancy, P\u00f4le \u201cMaladies du Vieillissement, G\u00e9rontologie et Soins Palliatifs,\u201d Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Bertin-Hugault","sequence":"additional","affiliation":[{"name":"Centre Borelli, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche (UMR) 9010\u2013DER Math\u00e9matiques, \u00c9cole Normale Sup\u00e9rieure Paris-Saclay, Gif sur Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Beuscart","sequence":"additional","affiliation":[{"name":"University of Lille, Centre Hospitalier Universitaire Lille, ULR 2694\u2013METRICS, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hanon","sequence":"additional","affiliation":[{"name":"University of Paris Cit\u00e9, UMR S 1144, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), Geriatric Department, Broca Hospital, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Karcher","sequence":"additional","affiliation":[{"name":"Geriatrics Unit, La Robertsau Geriatric Hospital, University Hospital of Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5518-9803","authenticated-orcid":false,"given":"Patrick","family":"Manckoundia","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and Internal Medicine, Hospital of Champmaillot, University Hospital, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Novella","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Reims University Hospitals, Maison Blanche Hospital, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdourahmane","family":"Diallo","sequence":"additional","affiliation":[{"name":"Clinical Trial Unit Hospital Lariboisi\u00e8re AP-HP, Universit\u00e9 Paris-Cit\u00e9, and FCRIN INI-CRCT, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vicaut","sequence":"additional","affiliation":[{"name":"Clinical Trial Unit Hospital Lariboisi\u00e8re AP-HP, Universit\u00e9 Paris-Cit\u00e9, and FCRIN INI-CRCT, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM, CIC-P 1433 CHRU Nancy and FCRIN INI-CRCT, Nancy, France"},{"name":"Medicine and Nephrology Department, Princess Grace Hospital, and M-CRIN, Monaco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801369"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.7050"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n189"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004223"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.8012"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17530"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05800"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.8164"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy072"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18373"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"e_1_3_4_14_2","first-page":"CD012572","article-title":"Withdrawal of antihypertensive drugs in older people.","volume":"3","author":"Gnjidic D","year":"2025","unstructured":"Gnjidic D, Langford AV, Jordan V, et al. Withdrawal of antihypertensive drugs in older people. Cochrane Database Syst Rev 2025;3:CD012572-CD012572.40162571","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060120024016"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2020.61"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.5770\/cgj.23.463"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab006"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4871"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(24)00131-4"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afae133"},{"key":"e_1_3_4_25_2","unstructured":"Sant\u00e9 Publique France. COVID-19 point \u00e9pid\u00e9miologique du 18 mars 2021. 2021 (https:\/\/www.santepubliquefrance.fr\/maladies-et-traumatismes\/maladies-et-infections-respiratoires\/infection-a-coronavirus\/documents\/bulletin-national\/covid-19-point-epidemiologique-du-18-mars-2021)."},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16472"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101677"},{"key":"e_1_3_4_28_2","first-page":"CD001841","article-title":"First-line drugs for hypertension.","volume":"4","author":"Wright JM","year":"2018","unstructured":"Wright JM, Musini VM, Gill R. First-line drugs for hypertension. Cochrane Database Syst Rev 2018;4:CD001841-CD001841.29667175","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017430"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02433-1"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18301"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2508157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T22:00:36Z","timestamp":1763589636000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2508157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":30,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,11,20]]}},"alternative-id":["10.1056\/NEJMoa2508157"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2508157","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]}}}