{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:56:12Z","timestamp":1792454172130,"version":"4.5.0"},"reference-count":23,"publisher":"Massachusetts Medical Society","issue":"9","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1 AI068634, UM1 AI068636, UM1 AI106701"],"award-info":[{"award-number":["UM1 AI068634, UM1 AI068636, UM1 AI106701"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,2,26]]},"DOI":"10.1056\/nejmoa2508228","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T22:01:23Z","timestamp":1771452083000},"page":"858-871","source":"Crossref","is-referenced-by-count":38,"title":["Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges"],"prefix":"10.1056","volume":"394","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-528X","authenticated-orcid":false,"given":"Aadia I.","family":"Rana","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham, Heersink School of Medicine, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Castillo-Mancilla","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Durham, NC"},{"name":"University of Colorado Anschutz Medical Campus, Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Bao","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sieczkarski","sequence":"additional","affiliation":[{"name":"Frontier Science Foundation, Amherst, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina M.","family":"Brooks","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus, Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Lake","sequence":"additional","affiliation":[{"name":"UTHealth Houston, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Fichtenbaum","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, Cincinnati"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya L.","family":"Heath","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Heersink School of Medicine, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo F.","family":"Belaunzaran-Zamudio","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH), Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Klingman","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH), Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Fox","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH), Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tia","family":"Morton","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH), Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stirratt","sequence":"additional","affiliation":[{"name":"Division of AIDS Research, National Institute of Mental Health, NIH, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Z.","family":"Li","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P.","family":"Acosta","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Heersink School of Medicine, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Venuto","sequence":"additional","affiliation":[{"name":"University of Rochester, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Gal\u00e1rraga","sequence":"additional","affiliation":[{"name":"Brown University School of Public Health, Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Shoptaw","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, David Geffen School of Medicine, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wohl","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill School of Medicine, Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Green","sequence":"additional","affiliation":[{"name":"Frontier Science Foundation, Amherst, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceora","family":"Beijer","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, David Geffen School of Medicine, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathie","family":"Ferbas","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, David Geffen School of Medicine, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Jennings","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Rush Core Laboratories, Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of AIDS, Pharmaceutical Affairs Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Collahua","sequence":"additional","affiliation":[{"name":"UTHealth Houston, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dorosh","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus, Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Wannamaker","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Smith","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Spreen","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati","family":"Vandermeulen","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodica","family":"Van Solingen-Ristea","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanelle","family":"Wimbish","sequence":"additional","affiliation":[{"name":"DLH, Advancing Clinical Therapeutics Globally for HIV\/AIDS and Other Infections (ACTG) Network Coordinating Center, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen T.","family":"Tashima","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University, Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael J.","family":"Landovitz","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, David Geffen School of Medicine, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600693"},{"key":"e_1_3_5_3_2","unstructured":"Centers for Disease Control and Prevention. Monitoring selected national HIV prevention and care objectives by using HIV surveillance data \u2014 United States and 6 territories and freely associated states 2023. 2025 (https:\/\/www.cdc.gov\/hiv-data\/nhss\/national-hiv-prevention-and-care-objectives-2025.html)."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.1343"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1909512"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904398"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32666-0"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad511"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaf120"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.0109"},{"key":"e_1_3_5_11_2","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Washington DC: Department of Health and Human Services 2025 (https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/adult-and-adolescent-arv)."},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.2985"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30233-4"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-019-02592-8"},{"key":"e_1_3_5_15_2","volume-title":"Group sequential methods with applications to clinical trials.","author":"Jennison C","year":"2000","unstructured":"Jennison C, Turnbull BW. Group sequential methods with applications to clinical trials. Boca Raton, FL: Chapman & Hall-CRC Press, 2000."},{"key":"e_1_3_5_16_2","unstructured":"Gant ZM Morales J Dailey A et al. Social determinants of health among adults with diagnosed HIV Infection in the United States and Puerto Rico 2020. HIV surveillance report: supplemental report. Vol. 28. No. 2. Atlanta: Centers for Disease Control and Prevention March 2023 (https:\/\/stacks.cdc.gov\/view\/cdc\/130299)."},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab330"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad370"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002883"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad202"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHH.0000000000001020"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00880-24"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae023"},{"key":"e_1_3_5_24_2","unstructured":"Dawson L Kates J. What do we know about people with HIV who are not engaged in regular HIV care? San Francisco: KFF June 22 2023 (https:\/\/www.kff.org\/hiv-aids\/what-do-we-know-about-people-with-hiv-who-are-not-engaged-in-regular-hiv-care\/)."}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2508228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:10:57Z","timestamp":1777050657000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2508228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,2,26]]}},"alternative-id":["10.1056\/NEJMoa2508228"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2508228","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}