{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:19:42Z","timestamp":1791598782887,"version":"4.3.4"},"reference-count":38,"publisher":"Massachusetts Medical Society","issue":"12","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100001009","name":"Bristol Myers Squibb Foundation","doi-asserted-by":"publisher","award":["GR0121870"],"award-info":[{"award-number":["GR0121870"]}],"id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2025,9,25]]},"DOI":"10.1056\/nejmoa2509426","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:15:59Z","timestamp":1756570559000},"page":"1166-1176","source":"Crossref","is-referenced-by-count":54,"title":["Apixaban for Extended Treatment of Provoked Venous Thromboembolism"],"prefix":"10.1056","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-5276","authenticated-orcid":false,"given":"Gregory","family":"Piazza","sequence":"first","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"},{"name":"Yale New Haven Hospital, Yale Center for Outcomes Research and Evaluation, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind K.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5405-2733","authenticated-orcid":false,"given":"Darsiya","family":"Krishnathasan","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candrika D.","family":"Khairani","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bejjani","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"},{"name":"Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth H.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Hogan","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Rashedi","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Pfeferman","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyang","family":"Lou","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fanikos","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"},{"name":"Department of Pharmacy, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Porio","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Sobieszczyk","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Lan","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"},{"name":"Center for Clinical Investigation, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gerhard-Herman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Campia","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Z.","family":"Goldhaber","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13336"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207541"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4363"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001830"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008828"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.055"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700518"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.07.044"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.367"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025471"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz405"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1646-2244"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.06.046"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.10.008"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031062"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-025-02706-4"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac776"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03678.x"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13140"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7046"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017719"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/81.3.515"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10516"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02842-3"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113697"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2015.21.10.965"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15533"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.12.030"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2021.1197"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac731"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-018-1762-7"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.120.003006"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2025.05.025"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.7326\/M22-3559"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001306"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2509426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T21:00:43Z","timestamp":1758747643000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2509426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,9,25]]}},"alternative-id":["10.1056\/NEJMoa2509426"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2509426","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,25]]}}}