{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:12:23Z","timestamp":1792084343931,"version":"4.4.0"},"reference-count":19,"publisher":"Massachusetts Medical Society","issue":"12","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"name":"Bank of Montreal","award":["Research Chair of pediatric immunology"],"award-info":[{"award-number":["Research Chair of pediatric immunology"]}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute, National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institutes of Health (NIH) per National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["ZIA AI000644"],"award-info":[{"award-number":["ZIA AI000644"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institutes of Health (NIH) per National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["ZIA AI000645"],"award-info":[{"award-number":["ZIA AI000645"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,3,26]]},"DOI":"10.1056\/nejmoa2509807","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T13:00:16Z","timestamp":1765112416000},"page":"1195-1203","source":"Crossref","is-referenced-by-count":35,"title":["Prime Editing for p47\n                    <sup>phox<\/sup>\n                    -Deficient Chronic Granulomatous Disease"],"prefix":"10.1056","volume":"394","author":[{"given":"Jennifer L.","family":"Gori","sequence":"first","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-6879","authenticated-orcid":false,"given":"Elie","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Azrieli Research Center, Universit\u00e9 de Montr\u00e9al, Montreal"},{"name":"Department of Microbiology, Immunology, and Infectious Diseases, CHU Sainte-Justine Azrieli Research Center, Universit\u00e9 de Montr\u00e9al, Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-2826","authenticated-orcid":false,"given":"Haydar","family":"Frangoul","sequence":"additional","affiliation":[{"name":"Sarah Cannon Research Institute, Children\u2019s Hospital at TriStar Centennial, Nashville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Kohn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma C.","family":"Morris","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley N.","family":"Martin","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briana A.","family":"Deary","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McKinley","family":"Nickerson","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Scholz","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Azrieli Research Center, Universit\u00e9 de Montr\u00e9al, Montreal"},{"name":"Department of Microbiology, Immunology, and Infectious Diseases, CHU Sainte-Justine Azrieli Research Center, Universit\u00e9 de Montr\u00e9al, Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Leveille","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Azrieli Research Center, Universit\u00e9 de Montr\u00e9al, Montreal"},{"name":"Department of Microbiology, Immunology, and Infectious Diseases, CHU Sainte-Justine Azrieli Research Center, Universit\u00e9 de Montr\u00e9al, Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk See","family":"De Ravin","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Kang","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Pierzynski","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyra","family":"Estwick","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Littel","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas B.","family":"Kuhns","sequence":"additional","affiliation":[{"name":"Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Long Priel","sequence":"additional","affiliation":[{"name":"Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Teira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Azrieli Research Center, Universit\u00e9 de Montr\u00e9al, Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Turvey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, British Columbia Children\u2019s Hospital, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordyn","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misty D.","family":"Evans","sequence":"additional","affiliation":[{"name":"Sarah Cannon Research Institute, Children\u2019s Hospital at TriStar Centennial, Nashville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghann","family":"McManus","sequence":"additional","affiliation":[{"name":"Sarah Cannon Research Institute, Children\u2019s Hospital at TriStar Centennial, Nashville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Hematology, University College London Hospitals NHS Foundation Trust, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Waterman","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew V.","family":"Anzalone","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Petrusich","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa E.","family":"Osuna","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiernan T.","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Stewart-Ornstein","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Heath","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barrett J.","family":"Nehilla","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Asmal","sequence":"additional","affiliation":[{"name":"Prime Medicine, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry L.","family":"Malech","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200005000-00003"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy008"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.636954"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005234"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.04.035"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018023184"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.305"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2021.102596"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1711-4"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2016001214"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.100919"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.04.015"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.10.1947"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3284"},{"key":"e_1_3_5_16_2","first-page":"2064","article-title":"3\u2032-End ligation sequencing is a sensitive method to detect DNA nicks at potential sites of off-target activity induced by prime editors.","volume":"35","author":"Stewart-Ornstein J","year":"2025","unstructured":"Stewart-Ornstein J, Irby MJ, Lilieholm MK, et al. 3\u2032-End ligation sequencing is a sensitive method to detect DNA nicks at potential sites of off-target activity induced by prime editors. Genome Res 2025;35:2064-2075.40764055","journal-title":"Genome Res"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201707922"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2113206"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309676"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2117175"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2509807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:00:48Z","timestamp":1774472448000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2509807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,3,26]]}},"alternative-id":["10.1056\/NEJMoa2509807"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2509807","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]}}}