{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:09:22Z","timestamp":1793293762431,"version":"4.5.0"},"reference-count":26,"publisher":"Massachusetts Medical Society","issue":"21","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100032128","name":"Taiho Oncology, Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032128","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,6,4]]},"DOI":"10.1056\/nejmoa2510223","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:00:26Z","timestamp":1780520426000},"page":"2107-2116","source":"Crossref","is-referenced-by-count":17,"title":["All-Oral Treatment of Newly Diagnosed Acute Myeloid Leukemia"],"prefix":"10.1056","volume":"394","author":[{"given":"Gail J.","family":"Roboz","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine, New York Presbyterian Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer M.","family":"Zeidan","sequence":"additional","affiliation":[{"name":"Yale University and Yale Comprehensive Cancer Center, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel N.","family":"Mannis","sequence":"additional","affiliation":[{"name":"Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Montesinos","sequence":"additional","affiliation":[{"name":"Hospital Universitari i Politecnic La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Arnan","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 d\u2019Oncologia, L\u2019Hospitalet de Llobregat, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Savona","sequence":"additional","affiliation":[{"name":"Vanderbilt\u2013Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olatoyosi","family":"Odenike","sequence":"additional","affiliation":[{"name":"University of Chicago Medicine and Comprehensive Cancer Center, Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"McCloskey","sequence":"additional","affiliation":[{"name":"John Theurer Cancer Center, Hackensack Medical Center, Hackensack, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshad V.","family":"Amin","sequence":"additional","affiliation":[{"name":"Boca Raton Clinical Research, Boca Raton, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir T.","family":"Fathi","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center\u2013Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Bernal del Castillo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias\u2013Instituto Universitario del Principado de Asturias\u2013Instituto Universitario de Oncolog\u00eda del Principado de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Rodr\u00edguez-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane L.","family":"Liesveld","sequence":"additional","affiliation":[{"name":"James P. Wilmot Cancer Institute, University of Rochester, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie P.","family":"Im","sequence":"additional","affiliation":[{"name":"University of Pittsburgh\u2013UPMC Hillman Cancer Center, Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Cerny","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School\u2013UMass Memorial Healthcare, Worcester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa C.","family":"Gentile","sequence":"additional","affiliation":[{"name":"State University of New York Upstate Medical University, Syracuse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Oganesian","sequence":"additional","affiliation":[{"name":"Taiho Oncology, Pleasanton, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Chan","sequence":"additional","affiliation":[{"name":"Taiho Oncology, Pleasanton, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Wan","sequence":"additional","affiliation":[{"name":"Taiho Oncology, Pleasanton, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Taiho Oncology, Pleasanton, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold N.","family":"Keer","sequence":"additional","affiliation":[{"name":"Taiho Oncology, Pleasanton, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center, Buffalo, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney D.","family":"DiNardo","sequence":"additional","affiliation":[{"name":"University of Texas M.D. Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","article-title":"American Society of Hematology 2025 guidelines for treating newly diagnosed acute myeloid leukemia in older adults.","author":"Sekeres MA","year":"2025","unstructured":"Sekeres MA, Mattison RJ, Artz AS, et al. American Society of Hematology 2025 guidelines for treating newly diagnosed acute myeloid leukemia in older adults. Blood Adv 2025 November 25 (Epub ahead of print).41321225","journal-title":"Blood Adv"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012971"},{"key":"e_1_3_5_4_2","unstructured":"Venclexta (venetoclax) prescribing information. 2022 (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/208573s027lbl.pdf)."},{"key":"e_1_3_5_5_2","unstructured":"Vidaza (azacitidine) prescribing information. 2022 (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/050974s034lbl.pdf)."},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30010-X"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19741"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02810"},{"key":"e_1_3_5_9_2","first-page":"1006","article-title":"Time spent at home among older adults with acute myeloid leukemia receiving azacitidine- or venetoclax-based regimens.","volume":"108","author":"Jensen CE","year":"2023","unstructured":"Jensen CE, Heiling HM, Beke KE, et al. Time spent at home among older adults with acute myeloid leukemia receiving azacitidine- or venetoclax-based regimens. Haematologica 2023;108:1006-1014.35861016","journal-title":"Haematologica"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00338-1"},{"key":"e_1_3_5_11_2","unstructured":"Inqovi (oral decitabine\/cedazuridine): U.S. prescribing information (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/212576s003lbl.pdf)."},{"key":"e_1_3_5_12_2","unstructured":"Inaqovi (oral decitabine\/cedazuridine) (https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/inaqovi-epar-product-information_en.pdf)."},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406207241257313"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-733196"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.22530"},{"key":"e_1_3_5_17_2","unstructured":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. Guideline for good clinical practice E6(R3): final version. January 2025 (https:\/\/database.ich.org\/sites\/default\/files\/ICH_E6%28R3%29_Step4_FinalGuideline_2025_0106.pdf)."},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025409"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27246"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27087"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024009"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014014"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279174"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2025.2544859"},{"key":"e_1_3_5_25_2","unstructured":"NCCN clinical practice guidelines in oncology: acute myeloid leukemia version 2. 2025 (https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/aml.pdf)."},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015832"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/10781552241238979"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2510223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:00:33Z","timestamp":1780520433000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2510223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":26,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2026,6,4]]}},"alternative-id":["10.1056\/NEJMoa2510223"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2510223","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]}}}