{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:38:23Z","timestamp":1792892303860,"version":"4.5.0"},"reference-count":24,"publisher":"Massachusetts Medical Society","issue":"13","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,4,2]]},"DOI":"10.1056\/nejmoa2511674","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T22:03:31Z","timestamp":1771452211000},"page":"1257-1269","source":"Crossref","is-referenced-by-count":135,"title":["Perioperative Enfortumab Vedotin and Pembrolizumab in Bladder Cancer"],"prefix":"10.1056","volume":"394","author":[{"given":"Christof","family":"Vulsteke","sequence":"first","affiliation":[{"name":"Integrated Cancer Center Ghent, AZ Maria Middelares, Ghent, Belgium"},{"name":"Center for Oncologic Research, Antwerp University, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-8329","authenticated-orcid":false,"given":"Nabil","family":"Adra","sequence":"additional","affiliation":[{"name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pongwut","family":"Danchaivijitr","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksym","family":"Sabadash","sequence":"additional","affiliation":[{"name":"Lviv State Regional Oncological Center, Lviv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejo","family":"Rodriguez-Vida","sequence":"additional","affiliation":[{"name":"Hospital del Mar, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Parkview Cancer Institute, Fort Wayne, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagif","family":"Atduev","sequence":"additional","affiliation":[{"name":"Volga District Medical Center, Federal Medical-Biologic Agency, Nizhny Novgorod, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Emre","family":"G\u00f6ger","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Rausch","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Ho","family":"Kang","sequence":"additional","affiliation":[{"name":"Korea University Anam Hospital, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Loriot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Gustave Roussy, INSERM Pr\u00e9dicteurs Mol\u00e9culaires et Nouvelles Cibles en Oncologie, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2778-3108","authenticated-orcid":false,"given":"Jens","family":"Bedke","sequence":"additional","affiliation":[{"name":"Eva Mayr-Stihl Cancer Center, Klinikum Stuttgart, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Galsky","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"University of Chicago, Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild","family":"von Amsberg","sequence":"additional","affiliation":[{"name":"University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimira","family":"Alimohamed","sequence":"additional","affiliation":[{"name":"Arthur J.E. Child Comprehensive Cancer Centre, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Sulimka","sequence":"additional","affiliation":[{"name":"Szpital Wojew\u00f3dzki im. \u015aw. \u0141ukasza, Tarnow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Taussig Cancer Institute, Cleveland Clinic, Cleveland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Paramonov","sequence":"additional","affiliation":[{"name":"Clinical Center of Oncology, Hematology, Transplantology and Palliative Care of the Cherkasy Oblast Council, Cherkasy, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Nakane","sequence":"additional","affiliation":[{"name":"Department of Urology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mihm","sequence":"additional","affiliation":[{"name":"Astellas Pharma, Northbrook, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changting","family":"Meng","sequence":"additional","affiliation":[{"name":"Pfizer, Bothell, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caizhi David","family":"Huang","sequence":"additional","affiliation":[{"name":"Merck, Rahway, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chethan","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"Merck, Rahway, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Homet Moreno","sequence":"additional","affiliation":[{"name":"Merck, Rahway, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Ull\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2013Pathology, Karolinska Institutet, Stockholm"},{"name":"Department of Pelvic Cancer, Genitourinary Oncology and Urology Unit, Karolinska University Hospital, Stockholm"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034442"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.11.012"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.04.006"},{"key":"e_1_3_5_5_2","unstructured":"NCCN clinical practice guidelines in oncology: bladder cancer (version 1.2025). National Comprehensive Cancer Network 2025 (https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/bladder.pdf)."},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2408154"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.JU.0001110168.15704.a3.34"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-020-00404-6"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22031"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.5_suppl.704"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70275-8"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.8433"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2023.12.008"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312117"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.03.001"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02887"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/19466315.2013.807748"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780091207"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/23523735251335122"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0440"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00094-2"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035807"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30616-2"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2401726"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.04.013"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2511674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:30:11Z","timestamp":1781742611000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2511674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":24,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,4,2]]}},"alternative-id":["10.1056\/NEJMoa2511674"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2511674","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]}}}