{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:09:39Z","timestamp":1790914179363,"version":"4.1.0"},"reference-count":24,"publisher":"Massachusetts Medical Society","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,5,28]]},"DOI":"10.1056\/nejmoa2513525","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:11:25Z","timestamp":1779916285000},"page":"1991-2001","source":"Crossref","is-referenced-by-count":16,"title":["Stem-Cell\u2013Derived Biologic Ventricular Assist Tissue in Heart Failure"],"prefix":"10.1056","volume":"394","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-4040","authenticated-orcid":false,"given":"Wolfram-Hubertus","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Cluster of Excellence Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, University of G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"German Center for Neurodegenerative Diseases, G\u00f6ttingen, Germany"},{"name":"German Center for Child and Adolescent Health, G\u00f6ttingen, Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ensminger","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Vascular Surgery, University Heart Center L\u00fcbeck, University Medical Center Schleswig Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"DZHK, partner site North, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Kutschka","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Paitazoglou","sequence":"additional","affiliation":[{"name":"DZHK, partner site North, L\u00fcbeck, Germany"},{"name":"Department of Cardiology, Angiology, and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Medical Center Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6158-5087","authenticated-orcid":false,"given":"Tim","family":"Seidler","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"Department of Cardiology, Campus Kerckhoff, Justus Liebig Universit\u00e4t Gie\u00dfen, Kerckhoff-Clinic, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5148-0997","authenticated-orcid":false,"given":"S\u00f6ren","family":"Brandenburg","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology of the German Heart Center Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin"},{"name":"DZHK, partner site Berlin, Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Bader","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Bergau","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bremmer","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Pathology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro G.","family":"Diogo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"DZHK, partner site North, L\u00fcbeck, Germany"},{"name":"Department of Cardiology, Angiology, and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Medical Center Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buntaro","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Vascular Surgery, University Heart Center L\u00fcbeck, University Medical Center Schleswig Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"DZHK, partner site North, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Gerecke","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Hasenfu\u00df","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Hellenkamp","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Hermann-Lingen","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad-Fawad","family":"Jebran","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Jurczyk","sequence":"additional","affiliation":[{"name":"DZHK, partner site North, L\u00fcbeck, Germany"},{"name":"Department of Cardiology, Angiology, and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Medical Center Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Knaus","sequence":"additional","affiliation":[{"name":"Repairon, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Legler","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Transfusion Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Lotz","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Institute of Cardiac Imaging, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Placzek","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Medical Statistics, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"P\u00fchler","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Vascular Surgery, University Heart Center L\u00fcbeck, University Medical Center Schleswig Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"DZHK, partner site North, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Riggert","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Transfusion Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Sadlonova","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Saraei","sequence":"additional","affiliation":[{"name":"DZHK, partner site North, L\u00fcbeck, Germany"},{"name":"Department of Cardiology, Angiology, and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Medical Center Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Str\u00f6bel","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Pathology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Tiburcy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Repairon, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-1888","authenticated-orcid":false,"given":"Jens-Uwe","family":"Voigt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Catholic University of Leuven, Leuven, Belgium"},{"name":"Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Walker","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Clinical Trial Unit, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Wollnik","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Cluster of Excellence Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, University of G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"German Center for Child and Adolescent Health, G\u00f6ttingen, Germany"},{"name":"Department of Human Genetics, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Yigit","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Human Genetics, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-7441","authenticated-orcid":false,"given":"Tim","family":"Friede","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Lower Saxony, G\u00f6ttingen, Germany"},{"name":"Department of Medical Statistics, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac013"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001016"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1236"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14076"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2021.05.009"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.124.012272"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.12.038"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000041435.95082.84"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5391.1145"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.12.013"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024145"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.12.005"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01098-8"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08463-0"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13233"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.04.010"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.064876"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.04.005"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.10.015"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00531-3"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1394"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66854"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2513525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:11:53Z","timestamp":1779916313000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2513525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":24,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,5,28]]}},"alternative-id":["10.1056\/NEJMoa2513525"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2513525","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]}}}