{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:20:44Z","timestamp":1792016444089,"version":"4.4.0"},"reference-count":21,"publisher":"Massachusetts Medical Society","issue":"9","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,2,26]]},"DOI":"10.1056\/nejmoa2514661","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:04:10Z","timestamp":1765393450000},"page":"845-857","source":"Crossref","is-referenced-by-count":79,"title":["Trastuzumab Deruxtecan in Residual HER2-Positive Early Breast Cancer"],"prefix":"10.1056","volume":"394","author":[{"given":"Sibylle","family":"Loibl","sequence":"first","affiliation":[{"name":"German Breast Group, Neu-Isenburg, Germany"},{"name":"Goethe University Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4156-9212","authenticated-orcid":false,"given":"Yeon Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Shao","sequence":"additional","affiliation":[{"name":"Fudan University Cancer Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiun-Sheng","family":"Huang","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Barrios","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Lucas, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jame","family":"Abraham","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleix","family":"Prat","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona, Barcelona"},{"name":"Department of Medicine, University of Barcelona, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Niikura","sequence":"additional","affiliation":[{"name":"Tokai University School of Medicine, Isehara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seock-Ah","family":"Im","sequence":"additional","affiliation":[{"name":"Seoul National University Hospital, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herui","family":"Yao","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen Memorial Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-zhi","family":"Geng","sequence":"additional","affiliation":[{"name":"Fourth Hospital of Heibei Medical University, Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuilbert","family":"Rodriguez Pantigoso","sequence":"additional","affiliation":[{"name":"Instituto Peruano de Oncolog\u00eda y Radioterapia, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Ram\u00edrez Godinez","sequence":"additional","affiliation":[{"name":"Hospital Civil de Guadalajara, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangui","family":"Song","sequence":"additional","affiliation":[{"name":"Union Hospital of Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ching Chang","sequence":"additional","affiliation":[{"name":"MacKay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Antoniazzi","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pio XII\u2013Hospital do C\u00e2ncer de Barretos, S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Cheh","family":"Chen","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigao","family":"Li","sequence":"additional","affiliation":[{"name":"Harbin Medical University Cancer Hospital, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Nowecki","sequence":"additional","affiliation":[{"name":"Maria Sk\u0142odowska-Curie Memorial Cancer Center, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joline","family":"Lim","sequence":"additional","affiliation":[{"name":"National University Cancer Institute, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elton","family":"Mathias","sequence":"additional","affiliation":[{"name":"Daiichi Sankyo, Basking Ridge, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Sato","sequence":"additional","affiliation":[{"name":"Clinical Science, Daiichi Sankyo, Rueil-Malmaison, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Lu","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Management, Daiichi Sankyo, Basking Ridge, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Abdel-Monem","sequence":"additional","affiliation":[{"name":"Clinical Science, Daiichi Sankyo, Basking Ridge, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Untch","sequence":"additional","affiliation":[{"name":"Health and Medical University, Breast Cancer Center, Helios Hospital Berlin\u2013Buch, Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Charles E.","family":"Geyer","sequence":"additional","affiliation":[{"name":"National Surgical Adjuvant Breast and Bowel Project (NSABP) Foundation, Pittsburgh"},{"name":"University of Pittsburgh School of Medicine\u2013UPMC Hillman Cancer Center, Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2025.105112"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00288-6"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814017"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2406070"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.11.016"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.04.011"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1914510"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00725-0"},{"key":"e_1_3_5_10_2","unstructured":"Enhertu (fam-trastuzumab deruxtecan-nxki) for injection for intravenous use: prescribing information. Basking Ridge NJ: Daiichi Sankyo March 10 2025 (https:\/\/daiichisankyo.us\/prescribing-information-portlet\/getPIContent?productName=Enhertu&inline=true)."},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104355"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115022"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203690"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2407086"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03261-7"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.8738"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03613"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1374547"},{"key":"e_1_3_5_19_2","unstructured":"National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: antiemesis. Version 2.2025 (https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=3&id=1415)."},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01296"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2023.102195"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021203427"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2514661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T22:00:51Z","timestamp":1772920851000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2514661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,2,26]]}},"alternative-id":["10.1056\/NEJMoa2514661"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2514661","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}