{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:07:58Z","timestamp":1791472078804,"version":"4.3.4"},"reference-count":40,"publisher":"Massachusetts Medical Society","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson & Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1056\/nejmoa2514752","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T21:30:12Z","timestamp":1765143012000},"page":"51-61","source":"Crossref","is-referenced-by-count":48,"title":["Dual Targeting of Extramedullary Myeloma with Talquetamab and Teclistamab"],"prefix":"10.1056","volume":"394","author":[{"given":"Shaji","family":"Kumar","sequence":"first","affiliation":[{"name":"Mayo Clinic Rochester, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Victoria","family":"Mateos","sequence":"additional","affiliation":[{"name":"University Hospital of Salamanca, Salamanca, Spain"},{"name":"Institute for Biomedical Research of Salamanca, Salamanca, Spain"},{"name":"The Salamanca Cancer Research Center, Salamanca, Spain"},{"name":"Centro de Investigacion Biomedica en Red Cancer, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Christine","family":"Ye","sequence":"additional","affiliation":[{"name":"M.D. Anderson Cancer Center, University of Texas, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-7534","authenticated-orcid":false,"given":"Shebli","family":"Atrash","sequence":"additional","affiliation":[{"name":"Levine Cancer Institute\u2013Atrium Health, Charlotte, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Magen","sequence":"additional","affiliation":[{"name":"Chaim Sheba Medical Center, Ramat-Gan, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Quach","sequence":"additional","affiliation":[{"name":"University of Melbourne, St. Vincent\u2019s Hospital, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Chu","sequence":"additional","affiliation":[{"name":"Alberta Health Services, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Trudel","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Richter","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Rodr\u00edguez-Otero","sequence":"additional","affiliation":[{"name":"Cancer Center Cl\u00ednica Universidad de Navarra, Cima, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hun","family":"Chuah","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Gatt","sequence":"additional","affiliation":[{"name":"Hadassah Medical Cener, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Medvedova","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute, Oregon Health and Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2739-2265","authenticated-orcid":false,"given":"Shahzad","family":"Raza","sequence":"additional","affiliation":[{"name":"Taussig Cancer Institute, Cleveland Clinic, Cleveland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dok Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadao","family":"Ishida","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Medical Center, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey V.","family":"Matous","sequence":"additional","affiliation":[{"name":"Colorado Blood Cancer Institute and Sarah Cannon Research Institute, Denver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rosi\u00f1ol","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Onodera","sequence":"additional","affiliation":[{"name":"Tohoku University Hospital, Sendai-shi, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Scott","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Heuck","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Zhang","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Henninger","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"O\u2019Rourke","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacristina","family":"Festa","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangxiu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikihiro","family":"Takamoto","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Pei","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashen","family":"Lu","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Au","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Krevvata","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad Z.","family":"Usmani","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael C.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky (Ichilov) Medical Center, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00643-3"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001459"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27023"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32030182"},{"key":"e_1_3_5_6_2","article-title":"Outcomes in patients with relapsed\/refractory multiple myeloma with extramedullary disease: a meta-analysis.","author":"Voorhees PM","unstructured":"Voorhees PM, Kumar S, Usmani SZ, et al. Outcomes in patients with relapsed\/refractory multiple myeloma with extramedullary disease: a meta-analysis. Ann Hematol (in press).","journal-title":"Ann Hematol"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.9290"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.065698"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00730-5"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17338"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2025.03.014"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024590"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025016619"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204591"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(24)00385-5"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"},{"key":"e_1_3_5_17_2","unstructured":"Janssen Biotech. Talvey (talquetamab-tgvs): prescribing information. August 2023 (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/761342s000lbl.pdf)."},{"key":"e_1_3_5_18_2","unstructured":"Janssen Biotech. Tecvayli (teclistamab-cqyv): prescribing information. August 2025 (https:\/\/www.janssenlabels.com\/package-insert\/product-monograph\/prescribing-information\/TECVAYLI-pi.pdf)."},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2406536"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30206-6"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-015-3200-9"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12041030"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30189-4"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00386"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31825b2071"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2024.2395440"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303379"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213614"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-181228"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02528-9"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01338-6"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-181857"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209900"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000843612.41180.42"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00372-6"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2024.05.003"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00879-7"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00159-6"},{"key":"e_1_3_5_41_2","doi-asserted-by":"crossref","first-page":"47671","DOI":"10.1182\/blood-2024-199752","article-title":"MonumenTAL-6: a phase 3 study of talquetamab + pomalidomide or talquetamab + teclistamab vs elotuzumab + pomalidomide + dexamethasone (EPd) or pomalidomide + bortezomib + dexamethasone (PVd) in patients with relapsed\/refractory multiple myeloma who received 1\u20134 prior lines of therapy, including lenalidomide and an anti-CD38 monoclonal antibody.","volume":"144","author":"Nooka AK","year":"2024","unstructured":"Nooka AK, Mian H, Lee C, et al. MonumenTAL-6: a phase 3 study of talquetamab + pomalidomide or talquetamab + teclistamab vs elotuzumab + pomalidomide + dexamethasone (EPd) or pomalidomide + bortezomib + dexamethasone (PVd) in patients with relapsed\/refractory multiple myeloma who received 1\u20134 prior lines of therapy, including lenalidomide and an anti-CD38 monoclonal antibody. Blood 2024;144:Suppl 1:47671-47671 (https:\/\/ashpublications.org\/blood\/article\/144\/Supplement%201\/4757.1\/530110\/Monumental-6-A-Phase-3-Study-of-Talquetamab).","journal-title":"Blood"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2514752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T17:00:27Z","timestamp":1767027627000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2514752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1056\/NEJMoa2514752"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2514752","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}