{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:07:42Z","timestamp":1792004862997,"version":"4.4.0"},"reference-count":30,"publisher":"Massachusetts Medical Society","issue":"21","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100022617","name":"Fisher and Paykel Healthcare","doi-asserted-by":"publisher","award":["grant"],"award-info":[{"award-number":["grant"]}],"id":[{"id":"10.13039\/501100022617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013392","name":"Minist\u00e8re de la Sant\u00e9 et des Services sociaux","doi-asserted-by":"publisher","award":["PHRC-19-0305"],"award-info":[{"award-number":["PHRC-19-0305"]}],"id":[{"id":"10.13039\/100013392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,6,4]]},"DOI":"10.1056\/nejmoa2516087","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:24:08Z","timestamp":1773757448000},"page":"2095-2106","source":"Crossref","is-referenced-by-count":17,"title":["High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure"],"prefix":"10.1056","volume":"394","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9176-7797","authenticated-orcid":false,"given":"Jean-Pierre","family":"Frat","sequence":"first","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, Centre Hospitalier Universitare (CHU) de Poitiers, Poitiers, France"},{"name":"INSERM, Centre d\u2019Investigation Clinique (CIC) 1402, IS-ALIVE, Universit\u00e9 de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Quenot","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, CHU Dijon\u2013Bourgogne, INSERM CIC 1432\u2013Equipe Lipness, Unite Mixt\u00e9 de Recherche (UMR) 1231, Universit\u00e9 Bourgogne\u2013Europe, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Guitton","sequence":"additional","affiliation":[{"name":"R\u00e9animation M\u00e9dico\u2013Chirurgicale, Centre Hospitalier (CH) Le Mans, Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Coudroy","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, Centre Hospitalier Universitare (CHU) de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Gacouin","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CHU de Rennes, H\u00f4pital Pontchaillou, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Badie","sequence":"additional","affiliation":[{"name":"H\u00f4pital Nord Franche\u2013Comt\u00e9, Tr\u00e9venans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-7217","authenticated-orcid":false,"given":"Alexandre","family":"Demoule","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), Groupe Hospitalier Universitaire AP-HP, Sorbonne Universit\u00e9, Site Piti\u00e9-Salp\u00eatri\u00e8re, M\u00e9decine Intensive et R\u00e9animation (D\u00e9partement R3S) and Sorbonne Universit\u00e9, Paris"},{"name":"INSERM, UMRS 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-507X","authenticated-orcid":false,"given":"Damien","family":"Contou","sequence":"additional","affiliation":[{"name":"R\u00e9animation Polyvalente et Unit\u00e9 de Surveillance Continue, CH Victor Dupouy, Argenteuil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Carteaux","sequence":"additional","affiliation":[{"name":"AP-HP, Service de M\u00e9decine Intensive R\u00e9animation, CHU Henri Mondor\u2013Albert Chenevier, Cr\u00e9teil, France"},{"name":"Facult\u00e9 de Sant\u00e9, Groupe de Recherche Clinique Cardiovascular and Respiratory Manifestations of Acute Lung Injury and Sepsis, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France"},{"name":"INSERM Unit\u00e9 955, Institut Mondor de Recherche Biom\u00e9dicale, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-4467","authenticated-orcid":false,"given":"Stephan","family":"Ehrmann","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CH Regional Universitaire de Tours, Tours, France"},{"name":"CIC INSERM 1415, Tours, France"},{"name":"Clinical Research in Intensive Care and Sepsis\u2013Trial Group for Global Evaluation and Research in Sepsis, French Clinical Research Infrastructure Network; Centre d\u2019\u00c9tude des Pathologies Respiratoires, INSERM Unit\u00e9 1100, Universit\u00e9 de Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Jarousseau","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Polyvalente, CH de Cholet, Cholet, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Sedillot","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Polyvalente, CH de Fleyriat, Bourg-en-Bresse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Rigaud","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CH de Dieppe, Dieppe, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3768-3496","authenticated-orcid":false,"given":"Jean","family":"Reignier","sequence":"additional","affiliation":[{"name":"Movement, Interactions, Performance Laboratory, UR 4334, Nantes Universit\u00e9, CHU Nantes, Nantes, France"},{"name":"Medical Intensive Care Unit, Nantes University Hospital, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Beloncle","sequence":"additional","affiliation":[{"name":"Vent\u2019Lab, Universit\u00e9 d\u2019Angers, Angers, France"},{"name":"D\u00e9partement de M\u00e9decine Intensive-R\u00e9animation et M\u00e9decine Hyperbare, CHU d\u2019Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Florence","family":"Dureau","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, Groupe Hospitalier de la R\u00e9gion de Mulhouse et Sud-Alsace, Mulhouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ferr\u00e9","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, CH de Versailles, Le Chesnay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Daubin","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, CHU de Caen Normandie, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bourreau","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CH de Bourges, Bourges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Delbove","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Polyvalente, CH Bretagne Atlantique, Vannes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Pradel","sequence":"additional","affiliation":[{"name":"R\u00e9animation, Centre Hospitalier Avignon, Avignon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhamid","family":"Fatah","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation, Groupement Hospitalier Nord-Dauphin\u00e9, Bourgoin-Jallieu, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenhael","family":"Colin","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, Centre Hospitalier D\u00e9partmental Vend\u00e9e, La Roche sur Yon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Deniel","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CHU La Croix Rousse, Hospices Civils de Lyon, Lyon, France"},{"name":"Institut National des Sciences Appliqu\u00e9es\u2013Lyon, Centre National de la Recherche Scientifique, INSERM, Center for Research in Acquisition and Signal Processing for Health, UMR 5220, INSERM Unit\u00e9 1294, Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lamouret","sequence":"additional","affiliation":[{"name":"R\u00e9animation Polyvalente, CH de Pau, Pau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"La Combe","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Polyvalente, Groupe Hospitalier Bretagne Sud, Lorient, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gw\u00e9na\u00ebl","family":"Prat","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CHU de Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis-Marie","family":"Galerneau","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CHU Grenoble Alpes, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Bourdin","sequence":"additional","affiliation":[{"name":"R\u00e9animation Polyvalente, H\u00f4pital Saint Joseph Saint Luc, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautier","family":"Julien","sequence":"additional","affiliation":[{"name":"R\u00e9animation et Surveillance Continue, CH de Saint Brieuc, Saint Brieuc, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-0923","authenticated-orcid":false,"given":"Ana\u00efs","family":"Curtiaud","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg, Strasbourg, France"},{"name":"F\u00e9d\u00e9ration Hospitalo-Universitaire TARGET, Service de M\u00e9decine Intensive R\u00e9animation, Nouvel H\u00f4pital Civil, H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France"},{"name":"INSERM, UMR 1260, Laboratory of Regenerative Nanomedicine, Strasbourg Research Federation of Translational Medicine, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Saint-L\u00e9ger","sequence":"additional","affiliation":[{"name":"R\u00e9animation, CH de P\u00e9rigueux, P\u00e9rigueux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Turbil","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation, CH Henri Mondor d\u2019Aurillac, Aurillac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faustine","family":"Reynaud","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, CH de Saint Nazaire, Saint Nazaire, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Chamblet","sequence":"additional","affiliation":[{"name":"INSERM CIC 1402, Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie de Poitiers, Universit\u00e9 de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Ragot","sequence":"additional","affiliation":[{"name":"INSERM CIC 1402, Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie de Poitiers, Universit\u00e9 de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud W.","family":"Thille","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, Centre Hospitalier Universitare (CHU) de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2169OC"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03317-2020"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503326"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02426-2016"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05536.x"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-0916OC"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00584.2016"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-226OC"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1504852"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.20714"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.15613"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-023-01208-8"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-024-01367-2"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-024-01389-w"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-083232"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-214863"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1870"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00096-0"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14282"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0578-8"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620956459"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.0028"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2215145"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30417-5"},{"key":"e_1_3_5_28_2","first-page":"980","article-title":"Prone positioning in the acute respiratory distress syndrome.","volume":"369","author":"Gu\u00e9rin C","year":"2013","unstructured":"Gu\u00e9rin C, Reignier J, Richard J-C. Prone positioning in the acute respiratory distress syndrome. N Engl J Med 2013;369:980-981.24004127","journal-title":"N Engl J Med"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.14901"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202303-0558WS"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500245"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2516087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:00:49Z","timestamp":1780520449000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2516087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":30,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2026,6,4]]}},"alternative-id":["10.1056\/NEJMoa2516087"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2516087","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]}}}