{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:56:24Z","timestamp":1791903384988,"version":"4.3.4"},"reference-count":33,"publisher":"Massachusetts Medical Society","issue":"14","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100019265","name":"Yuhan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cardiovascular Research Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,4,9]]},"DOI":"10.1056\/nejmoa2600283","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T20:45:47Z","timestamp":1774730747000},"page":"1365-1375","source":"Crossref","is-referenced-by-count":30,"title":["Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease"],"prefix":"10.1056","volume":"394","author":[{"given":"Yong-Joon","family":"Lee","sequence":"first","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hyup","family":"Lee","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwang-Sil","family":"Kim","sequence":"additional","affiliation":[{"name":"Sanggye Paik Hospital, Inje University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Man","family":"Cho","sequence":"additional","affiliation":[{"name":"Kyung Hee University Hospital at Gangdong, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong Chol","family":"Kang","sequence":"additional","affiliation":[{"name":"Gachon University Gil Medical Center, Incheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuck-Jun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Dongsan Hospital, Keimyung University, Daegu, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Eulji University Hospital, Daejeon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Soonchunhyang University Hospital, Cheonan, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Bae","family":"Lee","sequence":"additional","affiliation":[{"name":"Daegu Catholic University Hospital, Daegu, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Yong","family":"Jang","sequence":"additional","affiliation":[{"name":"National Health Insurance Service Ilsan Hospital, Goyang, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Ewha Womans University Seoul Hospital, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Uk","family":"Kwon","sequence":"additional","affiliation":[{"name":"Inje University Ilsan Paik Hospital, Goyang, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Jin","family":"Hong","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-4370","authenticated-orcid":false,"given":"Chul-Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2263-3274","authenticated-orcid":false,"given":"Jung-Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Guk","family":"Ko","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong-Ki","family":"Hong","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-3112","authenticated-orcid":false,"given":"Yangsoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong-Keuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf190"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.003"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw272"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040583"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050461"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.19.2437"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410489"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801174"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwaa047"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2024.06.012"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2526"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.06.046"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.03.039"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.07.006"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910355"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.9.1071"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.065"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.5218"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100665"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00916-3"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706444"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2514428"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.071"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy182"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029593"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.063399"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010012"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.01.016"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.2487"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2600283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:30:29Z","timestamp":1781742629000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2600283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":33,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,4,9]]}},"alternative-id":["10.1056\/NEJMoa2600283"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2600283","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]}}}