{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:07:03Z","timestamp":1792426023776,"version":"4.5.0"},"reference-count":29,"publisher":"Massachusetts Medical Society","issue":"1","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["288164"],"award-info":[{"award-number":["288164"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032581","name":"KLINBEFORSK","doi-asserted-by":"crossref","award":["201902"],"award-info":[{"award-number":["201902"]}],"id":[{"id":"10.13039\/100032581","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2023-02639"],"award-info":[{"award-number":["2023-02639"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region Stockholm","award":["FoUI-987565"],"award-info":[{"award-number":["FoUI-987565"]}]},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Fund","doi-asserted-by":"publisher","award":["FO2023-0336"],"award-info":[{"award-number":["FO2023-0336"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,7,2]]},"DOI":"10.1056\/nejmoa2600993","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:00:42Z","timestamp":1782939642000},"page":"44-53","source":"Crossref","is-referenced-by-count":8,"title":["Rituximab versus Ocrelizumab in Newly Diagnosed Relapsing Multiple Sclerosis"],"prefix":"10.1056","volume":"395","author":[{"given":"\u00d8ivind","family":"Torkildsen","sequence":"first","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde Kjelgaard","family":"Brustad","sequence":"additional","affiliation":[{"name":"Oslo Center for Biostatistics and Epidemiology, Oslo University Hospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einar August","family":"H\u00f8gest\u00f8l","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo"},{"name":"Department of Neurology, Oslo University Hospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Bj\u00f8rnar","family":"Alstadhaug","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nordland Hospital Trust, Bod\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Bhan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stavanger University Hospital, Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi \u00d8yen","family":"Flemmen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Telemark Hospital Trust, Skien, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Habbestad","sequence":"additional","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune A.A.","family":"H\u00f8glund","sequence":"additional","affiliation":[{"name":"Department of Neurology, Akershus University Hospital, Oslo"},{"name":"Institute of Basic Medical Sciences, University of Oslo, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Oslo Center for Biostatistics and Epidemiology, University of Oslo, Oslo"},{"name":"Department of Method Development and Analytics, Norwegian Institute of Public Health, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lopen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nord-Tr\u00f8ndelag Hospital Trust, Namsos, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5slaug Rudjord","family":"Lorentzen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo"},{"name":"Department of Neurology, S\u00f8rlandet Hospital Trust, Kristiansand, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5se Hagen","family":"Morsund","sequence":"additional","affiliation":[{"name":"Department of Neurology, M\u00f8re og Romsdal Hospital Trust, Molde, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Lossius","sequence":"additional","affiliation":[{"name":"Department of Neurology, Akershus University Hospital, Oslo"},{"name":"Institute of Basic Medical Sciences, University of Oslo, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rigmor","family":"Lundby","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo"},{"name":"Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gro O.","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo"},{"name":"Department of Neurology, Oslo University Hospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brit Ellen","family":"R\u00f8d","sequence":"additional","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Smith","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vestre Viken Hospital Trust, Drammen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"Steffensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital North Norway Trust, Troms\u00f8"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences, Arctic University of Norway, Troms\u00f8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Torgauten","sequence":"additional","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Piehl","sequence":"additional","affiliation":[{"name":"Department of Neurology, Karolinska University Hospital, Stockholm"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig","family":"Wergeland","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"},{"name":"Norwegian Multiple Sclerosis Registry and Biobank, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell-Morten","family":"Myhr","sequence":"additional","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf235"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11193-w"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.20588"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010135"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.2738"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706383"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61649-8"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25119"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1601277"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.4514"},{"key":"e_1_3_5_12_2","unstructured":"World Health Organization. WHO endorses landmark public health decisions on essential medicines for multiple sclerosis. July 26 2023 (https:\/\/www.who.int\/news\/item\/26-07-2023-who-endorses-landmark-public-health-decisions-on-essential-medicines-for-multiple-sclerosis)."},{"key":"e_1_3_5_13_2","first-page":"205521732096450","article-title":"A comparative study of tolerability and effects on immunoglobulin levels and CD19 cell counts with ocrelizumab vs low dose of rituximab in multiple sclerosis.","volume":"6","author":"Evertsson B","year":"2020","unstructured":"Evertsson B, Hoyt T, Christensen A, Nimer FA, Foley J, Piehl F. A comparative study of tolerability and effects on immunoglobulin levels and CD19 cell counts with ocrelizumab vs low dose of rituximab in multiple sclerosis. Mult Scler J Exp Transl Clin 2020;6:2055217320964505-2055217320964505.33110619","journal-title":"Mult Scler J Exp Transl Clin"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.1625"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.78033"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208063"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26914"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003331"},{"key":"e_1_3_5_19_2","first-page":"101171","article-title":"Could rituximab revolutionize multiple sclerosis treatment in Brazil? The missed opportunity for fewer relapses and lower costs.","volume":"49","author":"Silva GD","year":"2025","unstructured":"Silva GD, Pipek LZ, Oliveira MB, et al. Could rituximab revolutionize multiple sclerosis treatment in Brazil? The missed opportunity for fewer relapses and lower costs. Lancet Reg Health Am 2025;49:101171-101171.40688562","journal-title":"Lancet Reg Health Am"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917246"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00209-5"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.1961"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.38277"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ea15aa"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21606"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70103-0"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2016.1145549"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.171"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2025.106858"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2600993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:46:17Z","timestamp":1785879977000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2600993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7,2]]}},"alternative-id":["10.1056\/NEJMoa2600993"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2600993","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]}}}