{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:43:50Z","timestamp":1792122230713,"version":"4.4.0"},"reference-count":34,"publisher":"Massachusetts Medical Society","issue":"5","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson & Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,7,30]]},"DOI":"10.1056\/nejmoa2603870","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:01:06Z","timestamp":1780056066000},"page":"440-453","source":"Crossref","is-referenced-by-count":25,"title":["Teclistamab in Multiple Myeloma with One to Three Previous Lines of Therapy"],"prefix":"10.1056","volume":"395","author":[{"given":"Cyrille","family":"Touzeau","sequence":"first","affiliation":[{"name":"Department of Hematology, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mina","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Molecular Biotechnology and Health Sciences, Azienda Ospedaliero Universitaria Citt\u00e0 della Salute e della Scienza di Torino, University of Turin, Turin, Italy"},{"name":"Winship Cancer Institute, Emory University, Atlanta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Quach","sequence":"additional","affiliation":[{"name":"University of Melbourne, St. Vincent\u2019s Hospital Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania","family":"Hungria","sequence":"additional","affiliation":[{"name":"Clinica S\u00e3o Germano, S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divaya","family":"Bhutani","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarup","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Neag Comprehensive Cancer Center, UConn Health, Farmington, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4641-2217","authenticated-orcid":false,"given":"Chakra","family":"Chaulagain","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Myeloma and Amyloidosis Program, Cleveland Clinic Florida, Weston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios Athanasios","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens"},{"name":"Department of Medicine, Korea University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar J.","family":"Bahlis","sequence":"additional","affiliation":[{"name":"Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senem","family":"Maral","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels W.C.J.","family":"van de Donk","sequence":"additional","affiliation":[{"name":"Department of Hematology, Amsterdam University Medical Center, Cancer Center Amsterdam Vrije Universiteit Amsterdam, Amsterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayr","family":"Schmidt Filho","sequence":"additional","affiliation":[{"name":"Department of Hematology, A.C. Camargo Cancer Center, S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0271-8732","authenticated-orcid":false,"given":"Khalid","family":"Saja","sequence":"additional","affiliation":[{"name":"Hematology Department, Colchester Hospital, East Suffolk and North Essex NHS Foundation Trust, Colchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Teipel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Dresden, Technical University Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Hematology, Juntendo University School of Medicine, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Roeloffzen","sequence":"additional","affiliation":[{"name":"Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombretta","family":"Annibali","sequence":"additional","affiliation":[{"name":"Policlinico Universitario Campus Bio-Medico, Dipartimento di Medicina e Chirurgia Universit\u00e0 Campus Bio-Medico, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Augustson","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sir Charles Gairdner Hospital, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1522-4504","authenticated-orcid":false,"given":"Cirino","family":"Botta","sequence":"additional","affiliation":[{"name":"Hematology Unit, \u201cP. Giaccone\u201d University Hospital and Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Delforge","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Groupement des H\u00f4pitaux de l\u2019Institut Catholique de Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Buda","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Hus","sequence":"additional","affiliation":[{"name":"Medical University of Lublin, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-8689","authenticated-orcid":false,"given":"Aurore","family":"Perrot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulouse, Centre Hospitalier Universitaire, Service d\u2019Hematologie, Institut Universitaire du Cancer de Toulouse\u2013Oncopole, Cancer Research Center of Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meir","family":"Preis","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Lady Davis Carmel Medical Center, Haifa, Israel"},{"name":"University of Haifa, School of Medicine, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Beksac","sequence":"additional","affiliation":[{"name":"Department of Hematology, \u0130stinye University, Ankara Liv Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludek","family":"Pour","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Vejle Hospital, Vejle, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Hematology, Unidade Local de Sa\u00fade de Gaia e Espinho, Vila Nova de Gaia, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Oriol","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 d\u2019Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Melchardt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectiology, and Rheumatology, Cancer Research Laboratory of the Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Key Laboratory of Biological Targeted Therapy, Ministry of Education, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Flogeg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Falun General Hospital, Falun, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Wang","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Pei","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Wroblewski","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"Ari\u00ebs","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Quijano Card\u00e9","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Perova","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tertia","family":"de Jager","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Neuss, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Min","family":"Yeh","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Vanquickelberghe","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Shah","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, High Wycombe, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Chastain","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Kobos","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Carson","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Spring House, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-4839","authenticated-orcid":false,"given":"Ola","family":"Landgren","sequence":"additional","affiliation":[{"name":"Sylvester Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17071168"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00866-y"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2024.12.002"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07503-y"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303379"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405090"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403407"},{"key":"e_1_3_5_9_2","unstructured":"Tecvayli (teclistamab-cqyv) injection for subcutaneous use. Horsham PA: Janssen Biotech 2026 (package insert) (https:\/\/www.jnjlabels.com\/package-insert\/product-monograph\/prescribing-information\/TECVAYLI-pi.pdf)."},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2514663"},{"key":"e_1_3_5_11_2","doi-asserted-by":"crossref","unstructured":"Garfall AL Nooka AK van de Donk NWCJ et al. Long-term follow-up from the phase 1\/2 MajesTEC-1 trial of teclistamab in patients with relapsed\/refractory multiple myeloma. J Clin Oncol 2024;42:Suppl:7540-7540. abstract (https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2024.42.16_suppl.7540).","DOI":"10.1200\/JCO.2024.42.16_suppl.7540"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"},{"key":"e_1_3_5_13_2","unstructured":"European Medicines Agency. Imnovid (pomalidomide). EPAR summary of product characteristics. 2025 (https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/imnovid-epar-product-information_en.pdf)."},{"key":"e_1_3_5_14_2","unstructured":"Kyprolis (carfilzomib) for injection for intravenous use. Thousand Oaks CA: Amgen 2025 (package insert) (https:\/\/www.pi.amgen.com\/-\/media\/Project\/Amgen\/Repository\/pi-amgen-com\/Kyprolis\/kyprolis_pi.pdf)."},{"key":"e_1_3_5_15_2","unstructured":"European Medicines Agency. Kyprolis (carfilzomib). EPAR summary of product characteristics. 2024 (https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/kyprolis-epar-product-information_en.pdf)."},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00043-3"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-299487"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.290"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30206-6"},{"key":"e_1_3_5_20_2","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. November 27 2017 (https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/ctcae_v5_quick_reference_5x7.pdf)."},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30152-4"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010026"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00592-4"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00464-7"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7232"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406207221104584"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05385-8"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.70014"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-140056"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13532"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406207211035272"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2025.06.012"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011658"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02482-6"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2603870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:00:23Z","timestamp":1785358823000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2603870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,7,30]]}},"alternative-id":["10.1056\/NEJMoa2603870"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2603870","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}