{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:38:28Z","timestamp":1792852708338,"version":"4.5.0"},"reference-count":30,"publisher":"Massachusetts Medical Society","issue":"16","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,10,22]]},"DOI":"10.1056\/nejmoa2608717","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:00:41Z","timestamp":1787994041000},"page":"1575-1584","source":"Crossref","is-referenced-by-count":3,"title":["Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event"],"prefix":"10.1056","volume":"395","author":[{"given":"C. Michael","family":"Gibson","sequence":"first","affiliation":[{"name":"Baim Institute for Clinical Research, Boston"},{"name":"Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-2941","authenticated-orcid":false,"given":"P. Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Cit\u00e9, Paris"},{"name":"FACT (French Alliance for Cardiovascular Trials), Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Cecilia","family":"Bahit","sequence":"additional","affiliation":[{"name":"Baim Institute for Clinical Research, Boston"},{"name":"INECO Neurociencias, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Al-Lamee","sequence":"additional","affiliation":[{"name":"Imperial College London, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamir R.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Thrombosis and Atherosclerosis Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Mount Sinai, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Weitz","sequence":"additional","affiliation":[{"name":"Thrombosis and Atherosclerosis Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Goto","sequence":"additional","affiliation":[{"name":"Tokai University School of Medicine, Isehara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Carlos","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Instituto do Coracao, Hospital das Cl\u00ednicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato D.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Fudan University, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebojsa","family":"Tasic","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases Dedinje, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[{"name":"University of Florida, Jacksonville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne J.","family":"Baron","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-1058","authenticated-orcid":false,"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Xavier","sequence":"additional","affiliation":[{"name":"St. John\u2019s Medical College and Research Institute, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Tohoku University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil S.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Lady Davis Carmel Medical Center, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6643-0239","authenticated-orcid":false,"given":"Duk-Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Cornel","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Bristol Heart Institute, Clinical Sciences, University of Bristol, Bristol, United Kingdom"},{"name":"University Hospitals Bristol and Weston NHS Trust, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Trebacz","sequence":"additional","affiliation":[{"name":"Krak\u00f3w John Paul II Hospital, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Duerschmied","sequence":"additional","affiliation":[{"name":"University Medical Center Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Bode","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bela","family":"Merkely","sequence":"additional","affiliation":[{"name":"Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Dorobantu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos","family":"Vinereanu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Motovska","sequence":"additional","affiliation":[{"name":"Third Faculty of Medicine, Charles University and University Hospital Kr\u00e1lovsk\u00e9 Vinohrady, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Bueno","sequence":"additional","affiliation":[{"name":"National Center for Cardiovascular Research and Hospital 12 de Octubre, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Lopez-Sendon","sequence":"additional","affiliation":[{"name":"IdiPaz Research Institute, La Paz University Hospital, Madrid"},{"name":"Universidad Aut\u00f3noma de Madrid, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Ducrocq","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Cit\u00e9, Paris"},{"name":"FACT (French Alliance for Cardiovascular Trials), Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Italian National Institute for Cardiovascular Research, Bologna, Italy"},{"name":"University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Burgess","sequence":"additional","affiliation":[{"name":"TREAD Research, Cardiology Unit, Tygerberg Hospital, Parow, South Africa"},{"name":"Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Bohm","sequence":"additional","affiliation":[{"name":"Premedix, Bratislava, Slovakia"},{"name":"Comenius University, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chern-En","family":"Chiang","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Morais","sequence":"additional","affiliation":[{"name":"Hospital de Santo Andr\u00e9, Leiria, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Fong","sequence":"additional","affiliation":[{"name":"Sarawak Heart Centre, Kuching, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umit","family":"Guray","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Leiva-Pons","sequence":"additional","affiliation":[{"name":"Centro de Atenci\u00f3n e Investigaci\u00f3n Cardiovascular del Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Vranckx","sequence":"additional","affiliation":[{"name":"Hartcentrum Hasselt, Hasselt, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-6750","authenticated-orcid":false,"given":"Harvey D.","family":"White","sequence":"additional","affiliation":[{"name":"Auckland City Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasko","family":"Kedev","sequence":"additional","affiliation":[{"name":"University Clinic of Cardiology, Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Valgimigli","sequence":"additional","affiliation":[{"name":"Cardiocentro Ticino, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u0161ko","family":"Cerovec","sequence":"additional","affiliation":[{"name":"Special Hospital for Medical Rehabilitation Krapinske Toplice, Krapinske Toplice, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Tousoulis","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, Athens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Figtree","sequence":"additional","affiliation":[{"name":"University of Sydney, Sydney"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuong Dung","family":"Ho","sequence":"additional","affiliation":[{"name":"University Medical Center, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rody G.","family":"Sy","sequence":"additional","affiliation":[{"name":"UP-Philippine General Hospital Medical Center, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"B\u00f8ttcher","sequence":"additional","affiliation":[{"name":"Aarhus University, Aarhus, Denmark"},{"name":"G\u00f8dstrup Hospital, Herning, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Huber","sequence":"additional","affiliation":[{"name":"Austrian Heart Foundation, Vienna"},{"name":"Medical Private University Burgenland, Pinkafeld, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimvydas","family":"Slapikas","sequence":"additional","affiliation":[{"name":"Lithuanian University of Health Sciences, Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-0182","authenticated-orcid":false,"given":"Andrejs","family":"Erglis","sequence":"additional","affiliation":[{"name":"Pauls Stradins Clinical University Hospital, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Wei Chieh","family":"Tan","sequence":"additional","affiliation":[{"name":"National University Heart Centre Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Pincetti","sequence":"additional","affiliation":[{"name":"Temuco Regional Hospital, Temuco, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Pieper","sequence":"additional","affiliation":[{"name":"Thrombosis Research Institute, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Mahaffey","sequence":"additional","affiliation":[{"name":"Stanford University, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn S.P.","family":"Lam","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore, Singapore"},{"name":"Duke\u2013National University of Singapore Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Claiborne","family":"Johnston","sequence":"additional","affiliation":[{"name":"Dell Medical School, Austin, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme J.","family":"Hankey","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perron Institute for Neurological and Translational Science, Perth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Li","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Zheng","sequence":"additional","affiliation":[{"name":"Baim Institute for Clinical Research, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Aronson","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Lawrenceville, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danshi","family":"Li","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Lawrenceville, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Notani","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Vieira Pires","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Povsic","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair C.","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Plotnikov","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiaowei","family":"Deng","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot S.","family":"Barnathan","sequence":"additional","affiliation":[{"name":"Johnson & Johnson, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm15010047"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.03.003"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0954"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1160\/th14-03-0265"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158355"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.11.2489"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60738-8"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112277"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709118"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-025-01144-z"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.306925"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04653.x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00613"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2025.02.011"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2024.08.011"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2025.01.016"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2113194"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00403-9"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2026.02.020"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/10543406.2014.932285"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3538"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu505"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.061612"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2513880"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-024-00379-0"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2025.06.016"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15230"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2105872"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2608717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:05:34Z","timestamp":1792616734000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2608717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":30,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,10,22]]}},"alternative-id":["10.1056\/NEJMoa2608717"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2608717","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]}}}