{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:24:20Z","timestamp":1793021060262,"version":"4.5.0"},"reference-count":97,"publisher":"Massachusetts Medical Society","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2006,9,28]]},"DOI":"10.1056\/nejmra055323","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T21:38:00Z","timestamp":1159393080000},"page":"1345-1356","source":"Crossref","is-referenced-by-count":1530,"title":["The Tuberous Sclerosis Complex"],"prefix":"10.1056","volume":"355","author":[{"given":"Peter B.","family":"Crino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Nathanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Petri","family":"Henske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","first-page":"81","volume":"1","author":"Bourneville DM","year":"1880","journal-title":"Arch Neurol (Paris)"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1177\/088307389801301206"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1086\/316951"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63072-6"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000177497.31986.64"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(05)70343-2"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.05046.x"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-328"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1086\/514888"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(91)80261-5"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90689-2"},{"key":"r012","first-page":"1201","volume":"149","author":"Bjornsson J","year":"1996","journal-title":"Am J Pathol"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200409-1298OC"},{"key":"r014","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1164\/ajrccm.164.4.2011025","volume":"164","author":"Franz DN","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.4065\/75.6.591"},{"key":"r016","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0025-6196(12)61196-3","volume":"66","author":"Shepherd CW","year":"1991","journal-title":"Mayo Clin Proc"},{"key":"r017","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1177\/08830738040190090801","volume":"19","author":"Thiele EA","year":"2004","journal-title":"J Child Neurol"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00300-X"},{"key":"r019","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1177\/08830738040190090601","volume":"19","author":"Prather P","year":"2004","journal-title":"J Child Neurol"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026052421693"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1177\/088307389701200203"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00304-7"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050691"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00327.x"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.04009.x"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000168908.78118.99"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702007092"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.026815"},{"key":"r029","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1212\/01.WNL.0000142039.14522.1A","volume":"63","author":"Goh S","year":"2004","journal-title":"Neurology"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00494-3"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)91109-J"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1038\/ng0992-37"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90618-Z"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5327.805"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.1079"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201402"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1086\/302381"},{"key":"r038","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.12.2155"},{"key":"r039","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(199911)14:5<412::AID-HUMU7>3.0.CO;2-K"},{"key":"r040","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/jmg.36.4.285","volume":"36","author":"van Slegtenhorst M","year":"1999","journal-title":"J Med Genet"},{"key":"r041","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.11.1991"},{"key":"r042","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1994.tb01881.x"},{"key":"r043","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.1998.6240277.x"},{"key":"r044","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903043400905"},{"key":"r045","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.4.820"},{"key":"r046","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/jnen\/63.12.1236","volume":"63","author":"Chan JA","year":"2004","journal-title":"J Neuropathol Exp Neurol"},{"key":"r047","first-page":"400","volume":"59","author":"Henske EP","year":"1996","journal-title":"Am J Hum Genet"},{"key":"r048","doi-asserted-by":"publisher","DOI":"10.1086\/321972"},{"key":"r049","first-page":"4766","volume":"58","author":"Plank TL","year":"1998","journal-title":"Cancer Res"},{"key":"r050","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.6.1053"},{"key":"r051","first-page":"539","volume":"12","author":"Plank TL","year":"1999","journal-title":"Mod Pathol"},{"key":"r052","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880286"},{"key":"r053","first-page":"913","volume":"13","author":"Wienecke R","year":"1996","journal-title":"Oncogene"},{"key":"r054","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.2001.0307"},{"key":"r055","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi444"},{"key":"r056","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.10.6097"},{"key":"r057","first-page":"6475","volume":"62","author":"Liu MY","year":"2002","journal-title":"Cancer Res"},{"key":"r058","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401912200"},{"key":"r059","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2682"},{"key":"r060","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405528200"},{"key":"r061","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402790200"},{"key":"r062","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310208200"},{"key":"r063","doi-asserted-by":"publisher","DOI":"10.1038\/35010550"},{"key":"r064","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207211200"},{"key":"r065","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/jnen\/60.7.711","volume":"60","author":"Catania MG","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"r066","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207542"},{"key":"r067","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205792"},{"key":"r068","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402591200"},{"key":"r069","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300862200"},{"key":"r070","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405659101"},{"key":"r071","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.031"},{"key":"r072","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303956200"},{"key":"r073","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00929-2"},{"key":"r074","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.06.007"},{"key":"r075","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62958-6"},{"key":"r076","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00333-6"},{"key":"r077","doi-asserted-by":"publisher","DOI":"10.1101\/gad.901101"},{"key":"r078","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00332-4"},{"key":"r079","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00568-3"},{"key":"r080","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205838200"},{"key":"r081","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13044-9"},{"key":"r082","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202678200"},{"key":"r083","doi-asserted-by":"publisher","DOI":"10.1038\/ncb995"},{"key":"r084","doi-asserted-by":"publisher","DOI":"10.1038\/ncb996"},{"key":"r085","doi-asserted-by":"publisher","DOI":"10.1038\/ncb999"},{"key":"r086","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1110003"},{"key":"r087","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201276"},{"key":"r088","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.6085"},{"key":"r089","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-002-8651-8"},{"key":"r090","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200208-969OC"},{"key":"r091","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205962"},{"key":"r092","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20211"},{"key":"r093","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20234"},{"key":"r094","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.5.662"},{"key":"r095","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20118"},{"key":"r096","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20784"},{"key":"r097","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1314605"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMra055323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:25:58Z","timestamp":1683591958000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMra055323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,28]]},"references-count":97,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2006,9,28]]}},"alternative-id":["10.1056\/NEJMra055323"],"URL":"https:\/\/doi.org\/10.1056\/nejmra055323","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,28]]}}}