{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:28:52Z","timestamp":1793082532788,"version":"4.5.0"},"reference-count":75,"publisher":"Massachusetts Medical Society","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2019,5,16]]},"DOI":"10.1056\/nejmra1813799","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T17:01:21Z","timestamp":1557939681000},"page":"1941-1953","source":"Crossref","is-referenced-by-count":403,"title":["Muco-Obstructive Lung Diseases"],"prefix":"10.1056","volume":"380","author":[{"given":"Richard C.","family":"Boucher","sequence":"first","affiliation":[{"name":"From the Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1843CC"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.03.012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.04.008"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043184"},{"key":"e_1_3_3_6_2","unstructured":"Jones PW Forde Y. St George\u2019s respiratory questionnaire manual. London: St George\u2019s University of London 2009 (http:\/\/www.healthstatus.sgul.ac.uk\/SGRQ_download\/SGRQ%20Manual%20June%202009.pdf)."},{"key":"e_1_3_3_7_2","first-page":"1134","article-title":"Physiology of airway mucus secretion and pathophysiology of hypersecretion.","volume":"52","author":"Rogers DF","year":"2007","unstructured":"Rogers DF. Physiology of airway mucus secretion and pathophysiology of hypersecretion. Respir Care 2007;52:1134-1146.17716382","journal-title":"Respir Care"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95693"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910061"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73469"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701632"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1811787115"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2005"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223012"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.70.113006.100702"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","unstructured":"Rubinstein M Colby RH. Polymer physics. Oxford United Kingdom: Oxford University Press 2003.","DOI":"10.1093\/oso\/9780198520597.001.0001"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2230OC"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1934.03600040074006"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201804-0734OC"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.149310"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2014"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.1.8025763"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505832200"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/48.5.439"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003755"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.6985"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.7.3267-3275.1999"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.63"},{"key":"e_1_3_3_29_2","first-page":"6","article-title":"Inflammation: a two-edged sword \u2014 the model of bronchiectasis.","volume":"147","author":"Cole PJ","year":"1986","unstructured":"Cole PJ. Inflammation: a two-edged sword \u2014 the model of bronchiectasis. Eur J Respir Dis Suppl 1986;147:6-15.3533593","journal-title":"Eur J Respir Dis Suppl"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(03)00017-6"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1027OC"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301725"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0213870"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00767-15"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200708-1151OC"},{"key":"e_1_3_3_36_2","first-page":"229","article-title":"Bacterial microbiome of lungs in COPD.","volume":"9","author":"Sze MA","year":"2014","unstructured":"Sze MA, Hogg JC, Sin DD. Bacterial microbiome of lungs in COPD. Int J Chron Obstruct Pulmon Dis 2014;9:229-238.24591822","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.31"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005846"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606428103"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.117288"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200509-1525OC"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.060889"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201507-460AW"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12182"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00891-2015"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170622"},{"key":"e_1_3_3_47_2","first-page":"174","article-title":"The study of functional microanatomy of CF airways using clinical intranasal micro-OCT imaging.","volume":"53","author":"Leung HM","year":"2018","unstructured":"Leung HM, Birket S, Hyun C, et al. The study of functional microanatomy of CF airways using clinical intranasal micro-OCT imaging. Pediatr Pulmonol 2018;53:Suppl 2:174-174. abstract.","journal-title":"Pediatr Pulmonol"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav3488"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513818409041187"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201706-1139OC"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006798"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2015"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-192377"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00070.2005"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.186643"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S132961"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200709-1413OC"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2015.09.001"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1.118"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22984"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31767-7"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.7.3.213"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.3.198"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1434OC"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2290"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.10.055"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.09.064"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105185"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.04.003"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043891"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.09.007"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043900"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01770-2016"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00047504"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010525"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13047"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMra1813799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T20:52:22Z","timestamp":1711486342000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMra1813799"}},"subtitle":[],"editor":[{"given":"Jeffrey M.","family":"Drazen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":75,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,5,16]]}},"alternative-id":["10.1056\/NEJMra1813799"],"URL":"https:\/\/doi.org\/10.1056\/nejmra1813799","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735767989.793562174","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,16]]}}}