{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:16:15Z","timestamp":1787004975960,"version":"build-2736575974"},"reference-count":16,"publisher":"Massachusetts Medical Society","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2008,3,27]]},"DOI":"10.1056\/nejmsa0706341","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T19:28:28Z","timestamp":1206559708000},"page":"1354-1361","source":"Crossref","is-referenced-by-count":138,"title":["Drug-Review Deadlines and Safety Problems"],"prefix":"10.1056","volume":"358","author":[{"given":"Daniel","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan James","family":"Zucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Avorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1215\/03616878-29-3-397"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04776-0"},{"key":"r008","unstructured":"Avorn J. Powerful medicines: the benefits, risks, and costs of prescription drugs. New York: Knopf, 2004."},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp058003"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb053432"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.21.2647"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048286"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072761"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp078057"},{"key":"r016","unstructured":"FDA new molecular entity approval database, 1950\u20132004. Cambridge, MA: Department of Government, Faculty of Arts and Sciences, Harvard University. (Accessed March 3, 2008, athttp:\/\/people.hmdc.harvard.edu\/~dcarpent\/fdaproject.html.)"},{"key":"r017","unstructured":"Therneau TM, Grambsch PM. Modeling survival data: extending the Cox model. New York: Springer, 2000."},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.17.2215"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1177\/009286150103500134"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1198\/00031300283"},{"key":"r031","first-page":"W3","author":"Carpenter D","year":"2003","journal-title":"Health Aff (Millwood)"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp078032"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMsa0706341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T16:11:41Z","timestamp":1478103101000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMsa0706341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,27]]},"references-count":16,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2008,3,27]]}},"alternative-id":["10.1056\/NEJMsa0706341"],"URL":"https:\/\/doi.org\/10.1056\/nejmsa0706341","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,27]]}}}