{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:53:41Z","timestamp":1784138021441,"version":"3.55.0"},"reference-count":33,"publisher":"Massachusetts Medical Society","issue":"25","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Public Health Division of the Department of Health of the Autonomous Government of Catalonia","doi-asserted-by":"publisher","award":["Public Health Division of the Department of Health"],"award-info":[{"award-number":["Public Health Division of the Department of Health"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERobn"],"award-info":[{"award-number":["CIBERobn"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP06\/00100"],"award-info":[{"award-number":["CP06\/00100"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["P11\/02505"],"award-info":[{"award-number":["P11\/02505"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI 05\/2584"],"award-info":[{"award-number":["PI 05\/2584"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI 07\/0473"],"award-info":[{"award-number":["PI 07\/0473"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI04\/0954"],"award-info":[{"award-number":["PI04\/0954"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI07\/0240"],"award-info":[{"award-number":["PI07\/0240"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI07\/0954"],"award-info":[{"award-number":["PI07\/0954"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI07\/1138"],"award-info":[{"award-number":["PI07\/1138"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI10\/01407"],"award-info":[{"award-number":["PI10\/01407"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI10\/02658"],"award-info":[{"award-number":["PI10\/02658"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI11\/01647"],"award-info":[{"award-number":["PI11\/01647"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RTIC G03\/140"],"award-info":[{"award-number":["RTIC G03\/140"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RTIC RD06\/0045"],"award-info":[{"award-number":["RTIC RD06\/0045"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003425","name":"Departamento de Educaci\u00f3n, Gobierno de Navarra","doi-asserted-by":"publisher","award":["P27\/2011"],"award-info":[{"award-number":["P27\/2011"]}],"id":[{"id":"10.13039\/501100003425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["ACOMP06109"],"award-info":[{"award-number":["ACOMP06109"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["CS2010-AP-111"],"award-info":[{"award-number":["CS2010-AP-111"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["CS2011-AP-042"],"award-info":[{"award-number":["CS2011-AP-042"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["GVACOMP2010-181"],"award-info":[{"award-number":["GVACOMP2010-181"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["GVACOMP2011-151"],"award-info":[{"award-number":["GVACOMP2011-151"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["ME-1503-28119"],"award-info":[{"award-number":["ME-1503-28119"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["AGL-2009-13906-C02"],"award-info":[{"award-number":["AGL-2009-13906-C02"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["AGL2010-22319-C03"],"award-info":[{"award-number":["AGL2010-22319-C03"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005884","name":"Centro Nacional de Investigaciones Cardiovasculares","doi-asserted-by":"publisher","award":["CNIC 06\/2007"],"award-info":[{"award-number":["CNIC 06\/2007"]}],"id":[{"id":"10.13039\/501100005884","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejer\u00eda de Salud de la Junta de Andaluc\u00eda","award":["PI0105\/2007"],"award-info":[{"award-number":["PI0105\/2007"]}]},{"DOI":"10.13039\/501100003350","name":"Fundaci\u00f3n Mapfre","doi-asserted-by":"publisher","award":["Fundaci\u00f3n Mapfre 2010"],"award-info":[{"award-number":["Fundaci\u00f3n Mapfre 2010"]}],"id":[{"id":"10.13039\/501100003350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2018,6,21]]},"DOI":"10.1056\/nejmoa1800389","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T17:50:29Z","timestamp":1528912229000},"source":"Crossref","is-referenced-by-count":3002,"title":["Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts"],"prefix":"10.1056","volume":"378","author":[{"given":"Ram\u00f3n","family":"Estruch","sequence":"first","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Ros","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Salas-Salvad\u00f3","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Isabel","family":"Covas","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Corella","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Ar\u00f3s","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"G\u00f3mez-Gracia","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ruiz-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Fiol","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Lapetra","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Lamuela-Raventos","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Serra-Majem","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Pint\u00f3","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Basora","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 V.","family":"Sorl\u00ed","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alfredo","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Fit\u00f3","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Gea","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Hern\u00e1n","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Mart\u00ednez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"From the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) Network (RD 06\/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fit\u00f3, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.6.1402S"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29673"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111226"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.6.779"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.38"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.12.1440"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.5.964"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-1-200607040-00004"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708681"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200303"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13938"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1806491"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq250"},{"key":"e_1_3_5_15_2","unstructured":"PREDIMED home page (http:\/\/www.predimed.es\/)."},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2008.04.011"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.135566"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509993837"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.22.2449"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2998"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530245"},{"key":"e_1_3_5_22_2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.7326\/0003-4819-159-8-201310150-00709","article-title":"Randomized trials analyzed as observational studies.","volume":"159","author":"Hern\u00e1n MA","year":"2013","unstructured":"Hern\u00e1n MA, Hern\u00e1ndez-D\u00edaz S, Robins JM. Randomized trials analyzed as observational studies. Ann Intern Med 2013;159:560-562.24018844","journal-title":"Ann Intern Med"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsm1605385"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181df1b69"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.13.1823"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92580-1"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.000521"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318220abeb"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451200298X"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.9.1746S"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-010-0132-5"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2337"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.024216"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1800389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T23:27:51Z","timestamp":1751671671000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1800389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":33,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2018,6,21]]}},"alternative-id":["10.1056\/NEJMoa1800389"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1800389","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733441386.793550939","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.733441386.793552478","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,21]]}}}