{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:40:39Z","timestamp":1783953639044,"version":"3.55.0"},"reference-count":80,"publisher":"Massachusetts Medical Society","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2019,12,26]]},"DOI":"10.1056\/nejmra1905136","type":"journal-article","created":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T17:01:07Z","timestamp":1577293267000},"page":"2541-2551","source":"Crossref","is-referenced-by-count":1358,"title":["Effects of Intermittent Fasting on Health, Aging, and Disease"],"prefix":"10.1056","volume":"381","author":[{"given":"Rafael","family":"de Cabo","sequence":"first","affiliation":[{"name":"From the Translational Gerontology Branch (R.C.) and the Laboratory of Neurosciences (M.P.M.), Intramural Research Program, National Institute on Aging, National Institutes of Health, and the Department of Neuroscience, Johns Hopkins University School of Medicine (M.P.M.) \u2014 both in Baltimore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Mattson","sequence":"additional","affiliation":[{"name":"From the Translational Gerontology Branch (R.C.) and the Laboratory of Neurosciences (M.P.M.), Intramural Research Program, National Institute on Aging, National Institutes of Health, and the Department of Neuroscience, Johns Hopkins University School of Medicine (M.P.M.) \u2014 both in Baltimore."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710023371407"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4967"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau2095"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.12.008"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.156"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.01.003"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14063"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.05.001"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0061-0"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2011.07.001"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22065"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.011"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209353"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197003192821209"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P020867"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105621"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.12.005"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1991.10718184"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930584"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.171"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071816-064916"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105339"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.06.014"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/npjamd.2016.17"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.317"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1035720100"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513000792"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.12.006"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2011.00702.x"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2009.00533.x"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173635"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11432"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.02.019"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.69"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.11.001"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-1044-0"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S145247"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808587106"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2315"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852918001566"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.6.1921"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-006-9008-z"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308291101"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12400"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.08.005"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq168"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00261.2017"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.1189"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.1539"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv057"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/bs7010004"},{"key":"e_1_3_5_53_2","article-title":"Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin.","volume":"2018","author":"Furmli S","year":"2018","unstructured":"Furmli S, Elmasry R, Ramos M, Fung J. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. BMJ Case Rep 2018;2018:bcr-2017-221854.30301822","journal-title":"BMJ Case Rep"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.04.010"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.0936"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.036"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-9-98"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5263com"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2012.00825.x"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-12-146"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0873-x"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112000195"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-014-9495-3"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.60"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712162105"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00563.x"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12340"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2075-x"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00020"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.185"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.01.022"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09897-1"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12115"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.009"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.006"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.05.002"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1080\/030097401750065256"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.09.007"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.07.004"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.273"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.04.024"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMra1905136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T21:06:22Z","timestamp":1711487182000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMra1905136"}},"subtitle":[],"editor":[{"given":"Dan L.","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,26]]},"references-count":80,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2019,12,26]]}},"alternative-id":["10.1056\/NEJMra1905136"],"URL":"https:\/\/doi.org\/10.1056\/nejmra1905136","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737127718.793571885","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,26]]}}}