{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:30:30Z","timestamp":1792981830001,"version":"4.5.0"},"reference-count":13,"publisher":"Massachusetts Medical Society","issue":"27","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100004319","name":"BioNTech and Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2020,12,31]]},"DOI":"10.1056\/nejmoa2034577","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T09:07:05Z","timestamp":1607591225000},"page":"2603-2615","source":"Crossref","is-referenced-by-count":14335,"title":["Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine"],"prefix":"10.1056","volume":"383","author":[{"given":"Fernando P.","family":"Polack","sequence":"first","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Kitchin","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Absalon","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Gurtman","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lockhart","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Perez","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"P\u00e9rez Marc","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson D.","family":"Moreira","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Zerbini","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Bailey","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kena A.","family":"Swanson","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satrajit","family":"Roychoudhury","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Koury","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren V.","family":"Kalina","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cooper","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert W.","family":"Frenck","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) \u2014 both in New York; Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA; Associa\u00e7\u00e3o Obras Sociais Irm\u00e3 Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investiga\u00e7\u00e3o Clinica, S\u00e3o Paulo (C.Z.) \u2014 both in Brazil; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children\u2019s Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (\u00d6T., U.\u015e.), and Medizentrum Essen Borbeck, Essen (A.S.) \u2014 both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Hammitt","sequence":"additional","affiliation":[{"name":"From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires; 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