{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:24:30Z","timestamp":1792920270989,"version":"4.5.0"},"reference-count":33,"publisher":"Massachusetts Medical Society","issue":"4","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nejmgroup.org\/legal\/terms-of-use.htm"}],"funder":[{"DOI":"10.13039\/100019364","name":"Revolution Medicines","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2026,7,23]]},"DOI":"10.1056\/nejmoa2605555","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T12:01:09Z","timestamp":1780228869000},"page":"325-337","source":"Crossref","is-referenced-by-count":151,"title":["Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer"],"prefix":"10.1056","volume":"395","author":[{"given":"Eileen M.","family":"O\u2019Reilly","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zev A.","family":"Wainberg","sequence":"additional","affiliation":[{"name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Hendifar","sequence":"additional","affiliation":[{"name":"Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitesh J.","family":"Borad","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Pietrantonio","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Pant","sequence":"additional","affiliation":[{"name":"M.D. Anderson Cancer Center, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Hammel","sequence":"additional","affiliation":[{"name":"H\u00f4pital Paul-Brousse, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Saclay, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cremolini","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria Pisana and Universit\u00e0 di Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulam A.","family":"Manji","sequence":"additional","affiliation":[{"name":"Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Oberstein","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2013Oncology, NYU Langone Health, New York University, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Garrido-Laguna","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Springfeld","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, National Center for Tumor Diseases, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilofer S.","family":"Azad","sequence":"additional","affiliation":[{"name":"Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Y.","family":"Chui","sequence":"additional","affiliation":[{"name":"Revolution Medicines, Redwood City, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Revolution Medicines, Redwood City, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Patel","sequence":"additional","affiliation":[{"name":"Revolution Medicines, Redwood City, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonju","family":"Lee","sequence":"additional","affiliation":[{"name":"Revolution Medicines, Redwood City, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeena","family":"Salman","sequence":"additional","affiliation":[{"name":"Revolution Medicines, Redwood City, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Wolpin","sequence":"additional","affiliation":[{"name":"Hale Family Center for Pancreatic Cancer Research, Dana\u2013Farber Cancer Institute, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00298"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13027"},{"issue":"1","key":"e_1_3_5_4_2","first-page":"e70043","article-title":"Cancer statistics, 2026.","volume":"76","author":"Siegel RL","year":"2026","unstructured":"Siegel RL, Kratzer TB, Wagle NS, Sung H, Jemal A. Cancer statistics, 2026. CA Cancer J Clin 2026;76(1):e70043-e70043.41528114","journal-title":"CA Cancer J Clin"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21626"},{"key":"e_1_3_5_6_2","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. Cancer stat facts: pancreatic cancer (https:\/\/seer.cancer.gov\/statfacts\/html\/pancreas.html)."},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.08.009"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00840-w"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00795"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.5776"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.49720"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.12.007"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-1789"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102502"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02853-w"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.4_suppl.777"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16965"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.07.007"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.044"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07205-6"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01732-6"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03362-3"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-3930"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02314"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-24-0027"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1394702"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2505783"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_3_5_29_2","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. November 27 2017 (https:\/\/dctd.cancer.gov\/research\/ctep-trials\/for-sites\/adverse-events\/ctcae-v5-5x7.pdf)."},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5711"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01366-1"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-021-09990-2"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2605555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:00:29Z","timestamp":1784754029000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2605555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,23]]}},"alternative-id":["10.1056\/NEJMoa2605555"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa2605555","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]}}}